Abstract

This project deals with the 1) biochemical and antigenic differences present in HSV isolates and 2) the correlation of these differences with the pattern of ocular disease produced by these isolates. An animal model such as the New Zealand white rabbit is used for the quantitation and characterization of the disease. SDS-PAGE, restriction endonuclease analysis, and Southern blot technique, as well as protein blotting, are used for this work.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002389-10
Application #
3256741
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1979-04-01
Project End
1989-03-31
Budget Start
1988-04-01
Budget End
1989-03-31
Support Year
10
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Rootman, D S; Haruta, Y; Hill, J M (1990) Reactivation of HSV-1 in primates by transcorneal iontophoresis of adrenergic agents. Invest Ophthalmol Vis Sci 31:597-600
Haruta, Y; Rootman, D S; Xie, L X et al. (1989) Recurrent HSV-1 corneal lesions in rabbits induced by cyclophosphamide and dexamethasone. Invest Ophthalmol Vis Sci 30:371-6
Hobden, J A; O'Callaghan, R J; Hill, J M et al. (1989) Tobramycin iontophoresis into corneas infected with drug-resistant Pseudomonas aeruginosa. Curr Eye Res 8:1163-9
Rootman, D S; Hill, J M; Haruta, Y et al. (1989) Trifluridine decreases ocular HSV-1 recovery, but not herpetic lesions after timolol iontophoresis. Invest Ophthalmol Vis Sci 30:678-83
Haruta, Y; Rootman, D S; Hill, J M (1988) Recurrent HSV-1 corneal epithelial lesions induced by timolol iontophoresis in latently infected rabbits. Invest Ophthalmol Vis Sci 29:387-92
Rivera, L; Beuerman, R W; Hill, J M (1988) Corneal nerves contain intra-axonal HSV-1 after virus reactivation by epinephrine iontophoresis. Curr Eye Res 7:1001-8
Rootman, D S; Hobden, J A; Jantzen, J A et al. (1988) Iontophoresis of tobramycin for the treatment of experimental Pseudomonas keratitis in the rabbit. Arch Ophthalmol 106:262-5
Rootman, D S; Haruta, Y; Hill, J M et al. (1988) Corneal nerves are necessary for adrenergic reactivation of ocular herpes. Invest Ophthalmol Vis Sci 29:351-6
Rootman, D S; Jantzen, J A; Gonzalez, J R et al. (1988) Pharmacokinetics and safety of transcorneal iontophoresis of tobramycin in the rabbit. Invest Ophthalmol Vis Sci 29:1397-401
Hill, J M; Rayfield, M A; Haruta, Y (1987) Strain specificity of spontaneous and adrenergically induced HSV-1 ocular reactivation in latently infected rabbits. Curr Eye Res 6:91-7

Showing the most recent 10 out of 16 publications