Experiments based on physiologically-guided anatomy in the primate are proposed to help define how cortex related to visuo-oculomotor processing projects to basal ganglia, and how the main output from the basal ganglia to the superior colliculus (the nigrotectal pathway) is integrated with projections to the colliculus from the same areas of cortex. For the eye-movement related cortex, emphasis will be placed on comparing the connections of the classic prearcuate frontal eye field with those of the newly discovered supplementary eye field. We also propose to test whether inferior parietal cortex overlaps with the eye field projections. For the visual cortex, emphasis will be placed on discovering whether areas MT and V4 of the visual cortex project to the same or separate parts of the striatum and superior colliculus. The mosaic structure of the targets of these cortical outputs may be crucial to the further integration as well as to the segregation of these information lines. This issue will be studied by mapping the patchy inputs especially from the eye-field cortical areas and from MT and V4 of extrastriate cortex in relation to each other both in the matrix of the striatum and in the intermediate gray layer of the superior colliculus. The possibility that spatially distant parts of visuo-oculomotor related cortex project to nearby parts of the basal ganglia and superior colliculus thus will be tested. The ultimate goal of this work is to lay the foundation for an understanding of the role of the basal ganglia in visuo-oculomotor processing.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002866-14
Application #
3257165
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1978-12-01
Project End
1994-03-31
Budget Start
1993-04-01
Budget End
1994-03-31
Support Year
14
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Maloney, Laurence T; Mamassian, Pascal (2009) Bayesian decision theory as a model of human visual perception: testing Bayesian transfer. Vis Neurosci 26:147-55
Illing, R B; Graybiel, A M (1994) Pattern formation in the developing superior colliculus: ontogeny of the periodic architecture in the intermediate layers. J Comp Neurol 340:311-27
Flaherty, A W; Graybiel, A M (1994) Input-output organization of the sensorimotor striatum in the squirrel monkey. J Neurosci 14:599-610
Graybiel, A M; Illing, R B (1994) Enkephalin-positive and acetylcholinesterase-positive patch systems in the superior colliculus have matching distributions but distinct developmental histories. J Comp Neurol 340:297-310
Parthasarathy, H B; Schall, J D; Graybiel, A M (1992) Distributed but convergent ordering of corticostriatal projections: analysis of the frontal eye field and the supplementary eye field in the macaque monkey. J Neurosci 12:4468-88
Berson, D M; Graybiel, A M (1991) Tectorecipient zone of cat lateral posterior nucleus: evidence that collicular afferents contain acetylcholinesterase. Exp Brain Res 84:478-86
Ma, T P; Graybiel, A M; Wurtz, R H (1991) Location of saccade-related neurons in the macaque superior colliculus. Exp Brain Res 85:21-35
Berson, D M; Graybiel, A M; Bowen, W D et al. (1991) Evidence for intrinsic expression of enkephalin-like immunoreactivity and opioid binding sites in cat superior colliculus. Neuroscience 43:513-29
Ragsdale Jr, C W; Graybiel, A M (1991) Compartmental organization of the thalamostriatal connection in the cat. J Comp Neurol 311:134-67
Ragsdale Jr, C W; Graybiel, A M (1990) A simple ordering of neocortical areas established by the compartmental organization of their striatal projections. Proc Natl Acad Sci U S A 87:6196-9

Showing the most recent 10 out of 19 publications