The electroretinographic (ERG) abnormalities associated with diabetic retinopathy will be determined and related to the severity of retinopathy and to other visual function changes (color vision and visual fields). ERG parameters to be measured are the dark adapted b-wave amplitudes in response to an intensity series fit to the theoretical Naka-Rushton equation [(to compute R max (maximum response), K (half-saturation constant), n (slope of response function)], and the ERG oscillatory potentials (amplitude and implicit times). The ability of the electroretinogram and other visual function tests to identify eyes at risk to progress to the more severe retinopathy stages will be tested in a longitudinal 5-9 year study of 250 diabetic patients who are part of the Early Treatment Diabetic Retinopathy Study. The EGR parameters, alone and in conjunction with the Farnsworth-Munsell 100 hue test scores and Goldmann visual field scores at baseline will be related to the subsequent development of proliferative diabetic retinopathy. If these tests prove to have predictive value, they can be used in the future to select patients with high risk characteristics in order to institute earlier or more vigorous medical or surgical therapeutic intervention.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003084-10
Application #
3257383
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1979-04-01
Project End
1989-12-31
Budget Start
1988-04-01
Budget End
1989-12-31
Support Year
10
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Lutze, M; Bresnick, G H (1994) Lens-corrected visual field sensitivity and diabetes. Invest Ophthalmol Vis Sci 35:649-55
Roecker, E B; Pulos, E; Bresnick, G H et al. (1992) Characterization of the electroretinographic scotopic B-wave amplitude in diabetic and normal subjects. Invest Ophthalmol Vis Sci 33:1575-83
Bresnick, G H (1991) Assessment of the eye at risk of neovascularisation. Eye (Lond) 5 ( Pt 2):198-213
Lutze, M; Bresnick, G H (1991) Lenses of diabetic patients ""yellow"" at an accelerated rate similar to older normals. Invest Ophthalmol Vis Sci 32:194-9
Pulos, E (1989) Changes in rod sensitivity through adulthood. Invest Ophthalmol Vis Sci 30:1738-42
Bresnick, G H; Smith, V C; Pokorny, J (1989) Autosomal dominantly inherited macular dystrophy with preferential short-wavelength sensitive cone involvement. Am J Ophthalmol 108:265-76
Bresnick, G H (1989) Excitotoxins: a possible new mechanism for the pathogenesis of ischemic retinal damage. Arch Ophthalmol 107:339-41
Bresnick, G H; Palta, M (1987) Oscillatory potential amplitudes. Relation to severity of diabetic retinopathy. Arch Ophthalmol 105:929-33
Bresnick, G H; Palta, M (1987) Predicting progression to severe proliferative diabetic retinopathy. Arch Ophthalmol 105:810-4
Bresnick, G H; Palta, M (1987) Temporal aspects of the electroretinogram in diabetic retinopathy. Arch Ophthalmol 105:660-4

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