New techniques for photographing the nerve fiber layer and analyzing threshold perimetry have proved potentially sensitive and specific indices of early to mild glaucomatous optic nerve damage. During the second phase of this longitudinal prospective study over 1600 eyes with ocular hypertension, 250 with early glaucomatous field loss and an additional 200-400 normal controls will continue to undergo annual re-examination including masked, detailed manual kinetic and static perimetry, automated threshold perimetry, clinical assessment, color stereoscopic photography of the optic nerve head and red-free photography of the nerve fiber layer for an additional four years. Analysis will determine the sensitivity and specificity with which NFL assessment alone and, or in combination with other ocular, systemic and demographic factors, and with which threshold perimetry can identify individuals at risk of glaucomatous nerve damage (by manual perimetry or changes in cup-disc parameters, the existing """"""""gold standards"""""""") at annual intervals before such loss occurs. In addition, the natural history of ocular hypertension and correlative changes in these eyes will be established. Findings may result in new operative definitions of glaucoma for diagnostic and screening purposes, permitting effective and efficient intervention earlier in the disease process.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003605-09
Application #
3257991
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1981-09-01
Project End
1991-09-29
Budget Start
1989-09-30
Budget End
1990-09-29
Support Year
9
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Katz, J (2000) A comparison of the pattern- and total deviation-based Glaucoma Change Probability programs. Invest Ophthalmol Vis Sci 41:1012-6
Katz, J; Congdon, N; Friedman, D S (1999) Methodological variations in estimating apparent progressive visual field loss in clinical trials of glaucoma treatment. Arch Ophthalmol 117:1137-42
Katz, J (1999) Scoring systems for measuring progression of visual field loss in clinical trials of glaucoma treatment. Ophthalmology 106:391-5
Friedman, D S; Katz, J; Bressler, N M et al. (1999) Racial differences in the prevalence of age-related macular degeneration: the Baltimore Eye Survey. Ophthalmology 106:1049-55
Lietman, T; Eng, J; Katz, J et al. (1999) Neural networks for visual field analysis: how do they compare with other algorithms? J Glaucoma 8:77-80
Katz, J; Gilbert, D; Quigley, H A et al. (1997) Estimating progression of visual field loss in glaucoma. Ophthalmology 104:1017-25
Katz, J; Quigley, H A; Sommer, A (1996) Detection of incident field loss using the glaucoma hemifield test. Ophthalmology 103:657-63
Katz, J; Quigley, H A; Sommer, A (1995) Repeatability of the Glaucoma Hemifield Test in automated perimetry. Invest Ophthalmol Vis Sci 36:1658-64
Katz, J; Tielsch, J M; Quigley, H A et al. (1995) Automated perimetry detects visual field loss before manual Goldmann perimetry. Ophthalmology 102:21-6
Quigley, H A; Enger, C; Katz, J et al. (1994) Risk factors for the development of glaucomatous visual field loss in ocular hypertension. Arch Ophthalmol 112:644-9

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