Abstract

The goal of the research is to investigate the functional visual effects of different visual system anomalies using noninvasive tests of function. Basic psychophysical tests, which have been extensively used to study the properties of the normal visual system, are chosen carefully for the clinical situation. These clinical tests allow one to specifically address different levels of response within the visual system. Our present battery of tests includes measurement of retinal photoreceptor function, outer-plexiform and inner-plexiform layer function, optic pathway function (i.e., pre- or post-optic nerve head), and visual cortex function. These """"""""quantitative layer-by-layer perimetry"""""""" tests will enable the clinician or researcher to follow (across the various levels of visual processing and in selected visual field areas) the time course of progression, effectiveness of therapy and/or the natural remission of functional disruption. As part of the study of retinal photoreceptor function, we have special interest in the directional sensitivity of the retina, both from a basic and clinical point of view. In particular, we seek to understand mechanisms subserving photoreceptor alignment properties.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003674-08
Application #
3258083
Study Section
(SSS)
Project Start
1980-07-01
Project End
1991-07-31
Budget Start
1987-08-01
Budget End
1988-07-31
Support Year
8
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Type
Schools of Optometry/Opht Tech
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Lakshminarayanan, V; Parthasarathy, R; DeValois, K K (2000) A generalized perceptual space. Neurol Res 22:699-702
Lakshminarayanan, V; Bailey, J E; Enoch, J M (1997) Photoreceptor orientation and alignment in nasal fundus ectasia. Optom Vis Sci 74:1011-8
Hirose, H; Enoch, J M; Tuan, K M (1997) Quantification of prism induced metamorphopsia as a model for clinical retinal (and other) distortions. Ophthalmic Physiol Opt 17:239-47
Enoch, J M; Knowles, R (1995) Hyperacuity test to evaluate vision through dense cataracts;research preliminary to a clinical study. II. Initial trials of the India instrument and HASP protocol at Aravind Eye Hospital, Madurai, India. Optom Vis Sci 72:630-42
Enoch, J M; Schwartz, A; Chang, D et al. (1995) Aniseikonia, metamorphopsia and perceived entoptic pattern: some effects of a macular epiretinal membrane, and the subsequent spontaneous separation of the membrane. Ophthalmic Physiol Opt 15:339-43
Yebra-Pimentel Vilar, E; Giraldez-Fernandez, M J; Enoch, J M et al. (1995) Performance on three-point vernier acuity targets as a function of age. J Opt Soc Am A Opt Image Sci Vis 12:2293-304
Enoch, J M; Giraldez-Fernandez, M J; Knowles, R et al. (1995) Hyperacuity test to evaluate vision through dense cataracts;research preliminary to a clinical study. I. Studies conducted at the University of California at Berkeley before travel to India. Optom Vis Sci 72:619-29
Lakshminarayanan, V; Enoch, J M (1995) Vernier acuity and aging. Int Ophthalmol 19:109-15
Bailey, J E; Lakshminarayanan, V; Enoch, J M (1994) Photoreceptor orientation in iris coloboma. Optom Vis Sci 71:120-4
Lakshminarayanan, V; Bailey, J E; Enoch, J M (1993) Optics of phakic, pseudophakic, and aphakic eyes: effects on the Stiles-Crawford (SCE I) function. Optom Vis Sci 70:404-8

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