Our proposed research deals with environmental light damage to the retina of normal mice and rats and of those undergoing various forms of inherited retinal degeneration. Our goals are to clarify the cytopathologic steps in light damage due to fluorescent lighting, with particular emphasis on the involvement of the retinal pigment epithelium and eye pigmentation. We hope to define a genetic factor in susceptibility to light damage in otherwise normal retinas and to explore the role of the interphotoreceptor matrix in light damage. Our analysis of the influence of environmental lighting on several inherited retinal degenerations should offer useful guidelines on some aspects of the management of patients with retinitis pigmentosa.
| LaVail, M M; Gorrin, G M (1987) Protection from light damage by ocular pigmentation: analysis using experimental chimeras and translocation mice. Exp Eye Res 44:877-89 |
| LaVail, M M; Gorrin, G M; Repaci, M A et al. (1987) Genetic regulation of light damage to photoreceptors. Invest Ophthalmol Vis Sci 28:1043-8 |
| LaVail, M M; Gorrin, G M; Repaci, M A et al. (1987) Light-induced retinal degeneration in albino mice and rats: strain and species differences. Prog Clin Biol Res 247:439-54 |
| LaVail, M M; Papermaster, D S; Bridges, C D et al. (1987) Absence of an inherited retinal degeneration in the WAG/Rij rat. Exp Eye Res 44:465-9 |
| LaVail, M M; Gorrin, G M; Repaci, M A (1987) Strain differences in sensitivity to light-induced photoreceptor degeneration in albino mice. Curr Eye Res 6:825-34 |
| LaVail, M M; Lawson, N R (1986) Development of a congenic strain of pigmented and albino rats for light damage studies. Exp Eye Res 43:867-9 |
