Abstract

These studies will examine the adult structure and function of the macaque monkey striate visual cortex. The origins, cortical distribution patterns and physiological properties of different geniculo-cortical fiber populations will be investigated anatomically and physiologically. These studies will provide essential information concerning the input matrices from which the properties unique to visual cortex are then evolved. We will also explore the physiological properties of cortical neurons receiving these different geniculate fiber populations and the anatomical organization of their intrinsic axon relays within striate cortex. We hope in addition to provide more precise anatomical and physiological information concerning spatially ordered response patterns in populations of cortical neurons. Inhibitory circuits in the cortical neuropil will be explored using immunocytochemical means to identify the presence of glutamic acid decarboxylase (GAD), the synthetic enzyme for the inhibitory neuro-transmitter gamma-aminobutyric acid (GABA). Finally, the tree shrew visual cortex will be used as a model system to explore the nature and development of striate cortex intrinsic periodic lattice connections and the ordering of striate to prestriate projections. These approaches should improve our understanding of this crucial region of the primate visual system. The results should illustrate general principles that will be broadly applicable to other regions of the cerebral cortex and to the human nervous system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY005282-04
Application #
3260250
Study Section
Biopsychology Study Section (BPO)
Project Start
1983-08-01
Project End
1989-07-30
Budget Start
1986-08-01
Budget End
1987-07-31
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Levitt, J B; Yoshioka, T; Lund, J S (1995) Connections between the pulvinar complex and cytochrome oxidase-defined compartments in visual area V2 of macaque monkey. Exp Brain Res 104:419-30
Yoshioka, T; Levitt, J B; Lund, J S (1994) Independence and merger of thalamocortical channels within macaque monkey primary visual cortex: anatomy of interlaminar projections. Vis Neurosci 11:467-89
Levitt, J B; Yoshioka, T; Lund, J S (1994) Intrinsic cortical connections in macaque visual area V2: evidence for interaction between different functional streams. J Comp Neurol 342:551-70
Lund, J S; Lewis, D A (1993) Local circuit neurons of developing and mature macaque prefrontal cortex: Golgi and immunocytochemical characteristics. J Comp Neurol 328:282-312
Lund, J S; Yoshioka, T; Levitt, J B (1993) Comparison of intrinsic connectivity in different areas of macaque monkey cerebral cortex. Cereb Cortex 3:148-62
Levitt, J B; Lewis, D A; Yoshioka, T et al. (1993) Topography of pyramidal neuron intrinsic connections in macaque monkey prefrontal cortex (areas 9 and 46). J Comp Neurol 338:360-76
Craner, S L; Hoffman, G E; Lund, J S et al. (1992) cFos labeling in rat superior colliculus: activation by normal retinal pathways and pathways from intracranial retinal transplants. Exp Neurol 117:219-29
Yoshioka, T; Levitt, J B; Lund, J S (1992) Intrinsic lattice connections of macaque monkey visual cortical area V4. J Neurosci 12:2785-802
Chung, W W; Lagenaur, C F; Yan, Y M et al. (1991) Developmental expression of neural cell adhesion molecules in the mouse neocortex and olfactory bulb. J Comp Neurol 314:290-305
Lund, J S; Yoshioka, T (1991) Local circuit neurons of macaque monkey striate cortex: III. Neurons of laminae 4B, 4A, and 3B. J Comp Neurol 311:234-58

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