Studies of scotopic retinal function of normal human infants, ages 4 and 10 weeks, and adult control subjects are to be continued. The purpose is to further delineate the determinants of scotopic sensitivity and to consider mechanisms governing scotopic performance in normally developing human infants. Psychophysical, electroretinographic (ERG), pupillographic and optokinetic nystagmus (OKN) responses, each drawing from different levels of visual system activity, will, in and of themselves, give some information about the flow of scotopic signals along the visual pathways. Spectral sensitivity is to be studied in the detail necessary to make valid comparisons to extracted rhodopsin spectra. Also, the development of (1) ERG oscillatory potentials, (2) scotopic spatial vision (including """"""""Westheimer functions""""""""), and (30 dark adapted OKN thresholds are to be investigated. In the future the techniques and concepts evolving from these studies may be applied to the evaluation of human diseases.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY005325-05
Application #
3260363
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1980-09-30
Project End
1991-11-30
Budget Start
1987-03-01
Budget End
1987-11-30
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115