Clinical, electrophysiological, and anatomical studies indicate that the posterior parietal cortex of man and monkeys is important for visual-spatial perception. This proposal is a combined neurophysiological and neuroanatomical study which is designed to investigate how aspects of visuospatial perception might be encoded by the light-sensitive cell class of this region. This proposal has three specific aims: 1) to study the spatial interactions of visual stimuli in the large receptive fields of the light-sensitive neurons, 2) to study the effect of position of the eyes and head on light sensitivity, and 3) to study the functional anatomy of Area 7 with particular emphasis on the organization of visuospatial properties.
These aims will be achieved by recording the activity of single neurons from the posterior parietal cortex of behaving monkeys. The experimental animals will be trained to perform tasks designed to elucidate visuospatial properties of the light sensitive cells. Microelectrode mapping experiments will be combined with neuroanatomical tracing experiments to define functional subdivisions within this region and the local callosal and ipsilateral cortico-cortical inputs and outputs of these subdivisions. Data analysis will include the reconstruction of the population response of this region. Using the posterior parietal lobe as an example, inferences will be made of the role of homotypic cortex in higher functions.
| Graf, Arnulf B A; Andersen, Richard A (2015) Predicting oculomotor behaviour from correlated populations of posterior parietal neurons. Nat Commun 6:6024 |
| Andersen, Richard A; Andersen, Kristen N; Hwang, Eun Jung et al. (2014) Optic ataxia: from Balint's syndrome to the parietal reach region. Neuron 81:967-983 |
| Andersen, Richard A; Kellis, Spencer; Klaes, Christian et al. (2014) Toward more versatile and intuitive cortical brain-machine interfaces. Curr Biol 24:R885-R897 |
| Hwang, Eun Jung; Hauschild, Markus; Wilke, Melanie et al. (2014) Spatial and temporal eye-hand coordination relies on the parietal reach region. J Neurosci 34:12884-92 |
| Bremner, Lindsay R; Andersen, Richard A (2014) Temporal analysis of reference frames in parietal cortex area 5d during reach planning. J Neurosci 34:5273-84 |
| Graf, Arnulf Ba; Andersen, Richard A (2014) Inferring eye position from populations of lateral intraparietal neurons. Elife 3:e02813 |
| Graf, Arnulf B A; Andersen, Richard A (2014) Brain-machine interface for eye movements. Proc Natl Acad Sci U S A 111:17630-5 |
| Hwang, Eun Jung; Hauschild, Markus; Wilke, Melanie et al. (2012) Inactivation of the parietal reach region causes optic ataxia, impairing reaches but not saccades. Neuron 76:1021-9 |
| Bremner, Lindsay R; Andersen, Richard A (2012) Coding of the reach vector in parietal area 5d. Neuron 75:342-51 |
| Buneo, Christopher A; Andersen, Richard A (2012) Integration of target and hand position signals in the posterior parietal cortex: effects of workspace and hand vision. J Neurophysiol 108:187-99 |
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