Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY005798-09
Application #
2159595
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1988-03-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of New Hampshire
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
111089470
City
Durham
State
NH
Country
United States
Zip Code
03824

  Publications

Zeng-Elmore, Xiaohui; Gao, Xiong-Zhuo; Pellarin, Riccardo et al. (2014) Molecular architecture of photoreceptor phosphodiesterase elucidated by chemical cross-linking and integrative modeling. J Mol Biol 426:3713-3728
Zhang, Xiu-Jun; Gao, Xiong-Zhuo; Yao, Wei et al. (2012) Functional mapping of interacting regions of the photoreceptor phosphodiesterase (PDE6) ýý-subunit with PDE6 catalytic dimer, transducin, and regulator of G-protein signaling9-1 (RGS9-1). J Biol Chem 287:26312-20
Cahill, Karyn B; Quade, Jonathan H; Carleton, Karen L et al. (2012) Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6. J Biol Chem 287:41406-16
Matte, Suzanne L; Laue, Thomas M; Cote, Rick H (2012) Characterization of conformational changes and protein-protein interactions of rod photoreceptor phosphodiesterase (PDE6). J Biol Chem 287:20111-21
Cahill, Karyn B; Cote, Rick H (2011) Phosphodiesterase 6C, cGMP-specific cone alpha'. AFCS Nat Mol Pages 2011:
Gitschier, Hannah J; Cote, Rick H (2011) Phosphodiesterase 6D, cGMP-specific rod delta. AFCS Nat Mol Pages 2011:
Zhang, Xiu-Jun; Skiba, Nikolai P; Cote, Rick H (2010) Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin. J Biol Chem 285:4455-63
Liu, Yu-Ting; Matte, Suzanne L; Corbin, Jackie D et al. (2009) Probing the catalytic sites and activation mechanism of photoreceptor phosphodiesterase using radiolabeled phosphodiesterase inhibitors. J Biol Chem 284:31541-7
Zhang, Xiu-Jun; Cahill, Karyn B; Elfenbein, Arye et al. (2008) Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6. J Biol Chem 283:29699-705
Pentia, Dana C; Hosier, Suzanne; Cote, Rick H (2006) The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties. J Biol Chem 281:5500-5

Showing the most recent 10 out of 19 publications