Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY006164-02
Application #
3262195
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1987-09-30
Project End
1992-09-29
Budget Start
1988-09-30
Budget End
1989-09-29
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of South Carolina at Columbia
Department
Type
Schools of Medicine
DUNS #
111310249
City
Columbia
State
SC
Country
United States
Zip Code
29208
Kosnosky, W; Li, T H; Pakalnis, V A et al. (1994) Interleukin-1-beta changes the expression of metalloproteinases in the vitreous humor and induces membrane formation in eyes containing preexisting retinal holes. Invest Ophthalmol Vis Sci 35:4260-7
Hunt, R C; Pakalnis, V A; Choudhury, P et al. (1994) Cytokines and serum cause alpha 2 beta 1 integrin-mediated contraction of collagen gels by cultured retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 35:955-63
Hunt, R C; Fox, A; al Pakalnis, V et al. (1993) Cytokines cause cultured retinal pigment epithelial cells to secrete metalloproteinases and to contract collagen gels. Invest Ophthalmol Vis Sci 34:3179-86
Davis, A A; Hunt, R C (1993) Transferrin is made and bound by photoreceptor cells. J Cell Physiol 156:280-5
Hunt, R C; Davis, A A (1992) Release of iron by human retinal pigment epithelial cells. J Cell Physiol 152:102-10
Davis, A A; Whidby, D E; Privette, T et al. (1990) Selective inhibition of growing pigment epithelial cells by a receptor-directed immunotoxin. Invest Ophthalmol Vis Sci 31:2514-9
Hunt, R C; Davis, A A (1990) Altered expression of keratin and vimentin in human retinal pigment epithelial cells in vivo and in vitro. J Cell Physiol 145:187-99
Hunt, R C; Dewey, A; Davis, A A (1989) Transferrin receptors on the surfaces of retinal pigment epithelial cells are associated with the cytoskeleton. J Cell Sci 92 ( Pt 4):655-66
Hunt, R C; Riegler, R; Davis, A A (1989) Changes in glycosylation alter the affinity of the human transferrin receptor for its ligand. J Biol Chem 264:9643-8