Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY007355-06
Application #
2161470
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1988-09-30
Project End
1997-09-29
Budget Start
1994-09-30
Budget End
1997-09-29
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
Calvin, Harold I; Wu, Kaili; Li, Wenjie et al. (2003) Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A. Curr Eye Res 27:269-78
Li, Wenjie; Calvin, Harold I; David, Larry L et al. (2002) Altered patterns of phosphorylation in cultured mouse lenses during development of buthionine sulfoximine cataracts. Exp Eye Res 75:335-46
Calvin, H I; Zhu, G; Wu, J et al. (1997) Progression of mouse buthionine sulfoximine cataracts in vitro is inhibited by thiols or ascorbate. Exp Eye Res 65:341-7
Calvin, H I; Wu, J X; Viswanadhan, K et al. (1996) Modifications in lens protein biosynthesis signal the initiation of cataracts induced by buthionine sulfoximine in mice. Exp Eye Res 63:357-68
David, L L; Calvin, H I; Fu, S C (1994) Buthionine sulfoximine induced cataracts in mice contain insolubilized crystallins with calpain II cleavage sites. Exp Eye Res 59:501-4
Laver, N M; Robison Jr, W G; Calvin, H I et al. (1993) Early epithelial lesions in cataracts of GSH-depleted mouse pups. Exp Eye Res 57:493-8
Calvin, H I; Patel, S A; Zhang, J P et al. (1992) Progressive modifications of mouse lens crystallins in cataracts induced by buthionine sulfoximine. Exp Eye Res 54:611-9
Calvin, H I; von Hagen, S; Hess, J L et al. (1992) Lens GSH depletion and electrolyte changes preceding cataracts induced by buthionine sulfoximine in suckling mice. Exp Eye Res 54:621-6
Calvin, H I; Medvedovsky, C; David, J C et al. (1991) Rapid deterioration of lens fibers in GSH-depleted mouse pups. Invest Ophthalmol Vis Sci 32:1916-24