Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY007774-02
Application #
3264856
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1988-08-01
Project End
1993-07-31
Budget Start
1989-08-01
Budget End
1990-07-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Brown University
Department
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Isayama, Tomoki; McCabe England, S L; Crouch, R K et al. (2009) Beta-ionone activates and bleaches visual pigment in salamander photoreceptors. Vis Neurosci 26:267-74
He, Quanhua; Alexeev, Dmitriy; Estevez, Maureen E et al. (2006) Cyclic nucleotide-gated ion channels in rod photoreceptors are protected from retinoid inhibition. J Gen Physiol 128:473-85
Horrigan, Diana M; Tetreault, Michelle L; Tsomaia, Natia et al. (2005) Defining the retinoid binding site in the rod cyclic nucleotide-gated channel. J Gen Physiol 126:453-60
McCabe, Sarah L; Pelosi, Diana M; Tetreault, Michelle et al. (2004) All-trans-retinal is a closed-state inhibitor of rod cyclic nucleotide-gated ion channels. J Gen Physiol 123:521-31
Dean, Dylan M; Nguitragool, Wang; Miri, Andrew et al. (2002) All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light? Proc Natl Acad Sci U S A 99:8372-7
Crary, J I; Dean, D M; Maroof, F et al. (2000) Mutation of a single residue in the S2-S3 loop of CNG channels alters the gating properties and sensitivity to inhibitors. J Gen Physiol 116:769-80
Crary, J I; Dean, D M; Nguitragool, W et al. (2000) Mechanism of inhibition of cyclic nucleotide-gated ion channels by diacylglycerol. J Gen Physiol 116:755-68
Crary, J I; Gordon, S E; Zimmerman, A L (1998) Perfusion system components release agents that distort functional properties of rod cyclic nucleotide-gated ion channels. Vis Neurosci 15:1189-93
Gordon, S E; Downing-Park, J; Tam, B et al. (1995) Diacylglycerol analogs inhibit the rod cGMP-gated channel by a phosphorylation-independent mechanism. Biophys J 69:409-17
Gordon, S E; Downing-Park, J; Zimmerman, A L (1995) Modulation of the cGMP-gated ion channel in frog rods by calmodulin and an endogenous inhibitory factor. J Physiol 486 ( Pt 3):533-46

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