The long term objective of the project is a complete description of how the two and three-dimensional structure of objects or the environment can be obtained from visual motion in human subjects. The awake behaving monkey is used as a model for such visual processing. Previous studies (Siegel and Andersen, 1988) indicate both species have similar motion psychophysics using highly controlled stimuli consisting of large numbers of moving dots validating the use of the non-human primate as a model for human subjects. Electrophysiological recordings in the awake behaving monkey will be used to explore higher level motion processing. Single neurons will be recorded while the monkey is performing the earlier published psychophysical tasks. The recording study will first phenomenologically describe the properties of neurons in the cortical visual areas of the inferior parietal lobule and """"""""anatomically near"""""""" cortex when presented with the structure from motion stimulus. The receptive field structures of these neurons will be examined in order to determine if the response may be explained by local receptive field mechanisms. A comparison will be made between the response of the neurons to the random dot stimuli and to the movement of bars which have the same underlying motion transformation. Finally, the interactions between the motion stimulus and the position of the eye in the orbit will be explored in an attempt to understand how motion is used in the perception of surrounding space. This study is related to the mental health of individuals in that it seeks to understand how is of incoming visual stimuli is performed by the inferior parietal lobule. The understanding of such mechanisms is necessary in understanding the damage that occurs following stroke and other cerebral compromise.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY009223-01A2
Application #
3266596
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1993-09-30
Project End
1997-09-29
Budget Start
1993-09-30
Budget End
1994-09-29
Support Year
1
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Rutgers University
Department
Type
Organized Research Units
DUNS #
130029205
City
Newark
State
NJ
Country
United States
Zip Code
07102
Heider, Barbara; Siegel, Ralph M (2014) Optical imaging of visually guided reaching in macaque posterior parietal cortex. Brain Struct Funct 219:495-509
Karkhanis, Anushree N; Heider, Barbara; Silva, Fabian Muñoz et al. (2014) Spatial effects of shifting prisms on properties of posterior parietal cortex neurons. J Physiol 592:3625-46
Heider, Barbara; Karnik, Anushree; Ramalingam, Nirmala et al. (2010) Neural representation during visually guided reaching in macaque posterior parietal cortex. J Neurophysiol 104:3494-509
Khaytin, Ilya; Chen, Xin; Royal, David W et al. (2008) Functional organization of temporal frequency selectivity in primate visual cortex. Cereb Cortex 18:1828-42
Quraishi, Salma; Heider, Barbara; Siegel, Ralph M (2007) Attentional modulation of receptive field structure in area 7a of the behaving monkey. Cereb Cortex 17:1841-57
Siegel, Ralph M; Duann, Jeng-Ren; Jung, Tzyy-Ping et al. (2007) Spatiotemporal dynamics of the functional architecture for gain fields in inferior parietal lobule of behaving monkey. Cereb Cortex 17:378-90
Raffi, Milena; Siegel, Ralph M (2005) Functional architecture of spatial attention in the parietal cortex of the behaving monkey. J Neurosci 25:5171-86
Anderson, Kathleen C; Siegel, Ralph M (2005) Three-dimensional structure-from-motion selectivity in the anterior superior temporal polysensory area, STPa, of the behaving monkey. Cereb Cortex 15:1299-307
Heider, Barbara; Jando, Gabor; Siegel, Ralph M (2005) Functional architecture of retinotopy in visual association cortex of behaving monkey. Cereb Cortex 15:460-78
Turner, J A; Anderson, K C; Siegel, R M (2003) Cell responsiveness in macaque superior temporal polysensory area measured by temporal discriminants. Neural Comput 15:2067-90

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