Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY009331-06
Application #
2162934
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1991-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Pathology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Hsiao, Victoria C; Tian, Rujin; Long, Heather et al. (2005) Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP. J Cell Sci 118:2057-65
Li, Rong; Messing, Albee; Goldman, James E et al. (2002) GFAP mutations in Alexander disease. Int J Dev Neurosci 20:259-68
Brenner, M; Johnson, A B; Boespflug-Tanguy, O et al. (2001) Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nat Genet 27:117-20
Head, M W; Hurwitz, L; Kegel, K et al. (2000) AlphaB-crystallin regulates intermediate filament organization in situ. Neuroreport 11:361-5
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Koyama, Y; Goldman, J E (1999) Formation of GFAP cytoplasmic inclusions in astrocytes and their disaggregation by alphaB-crystallin. Am J Pathol 154:1563-72
Wisniewski, T; Goldman, J E (1998) Alpha B-crystallin is associated with intermediate filaments in astrocytoma cells. Neurochem Res 23:385-92
Messing, A; Head, M W; Galles, K et al. (1998) Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice. Am J Pathol 152:391-8
Chin, S S; Goldman, J E (1996) Glial inclusions in CNS degenerative diseases. J Neuropathol Exp Neurol 55:499-508
Kegel, K B; Iwaki, A; Iwaki, T et al. (1996) AlphaB-crystallin protects glial cells from hypertonic stress. Am J Physiol 270:C903-9

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