Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY009531-04
Application #
2163116
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1992-12-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Enz, R; Cutting, G R (1999) GABAC receptor rho subunits are heterogeneously expressed in the human CNS and form homo- and heterooligomers with distinct physical properties. Eur J Neurosci 11:41-50
Enz, R; Ross, B J; Cutting, G R (1999) Expression of the voltage-gated chloride channel ClC-2 in rod bipolar cells of the rat retina. J Neurosci 19:9841-7
Enz, R; Cutting, G R (1999) Identification of 70 amino acids important for GABA(C) receptor rho1 subunit assembly. Brain Res 846:177-85
Hackam, A S; Wang, T L; Guggino, W B et al. (1998) Sequences in the amino termini of GABA rho and GABA(A) subunits specify their selective interaction in vitro. J Neurochem 70:40-6
Enz, R; Cutting, G R (1998) Molecular composition of GABAC receptors. Vision Res 38:1431-41
Hackam, A S; Wang, T L; Guggino, W B et al. (1997) The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction. J Biol Chem 272:13750-7
Hackam, A S; Wang, T L; Guggino, W B et al. (1997) A 100 amino acid region in the GABA rho 1 subunit confers robust homo-oligomeric expression. Neuroreport 8:1425-30
Wang, T L; Hackam, A; Guggino, W B et al. (1995) A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors. J Neurosci 15:7684-91
Wang, T L; Hackam, A S; Guggino, W B et al. (1995) A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition. Proc Natl Acad Sci U S A 92:11751-5