Uveitis is a major cause of blindness in the United States. Pars planitis is a well- defined disease subset of uveitis. The cause of pars planitis, as well as other forms of uveitis, is frequently unknown. The PI has identified a 36 kDa protein (p-36) which is markedly increased in the peripheral blood of patients with active pars planitis. Recent results from the laboratory suggest that p-36 is a part of a larger protein which is approximately 95 kD (p-95) in size. The identification of proteins which may contribute to the pathogenesis of pars planitis would be a major advance toward its treatment and possible cure.
The specific aims of this proposal are: A. To correlate levels of p-36 and p-95 with clinical disease in pars planitis. B. To determine the structure of p-95. C. To study the tissue distribution of p-95. Quantitative assessment of p-36 and p-95 levels in patients; blood may be of value in both monitoring disease activity and guiding treatment. The PI hopes that the proposed studies will allow the uncovering of important information concerning the mechanism of ocular inflammation in pars planitis, and possibly, to design more effective treatment for this disease.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
7R01EY009730-07
Application #
6412458
Study Section
Visual Sciences A Study Section (VISA)
Program Officer
Liberman, Ellen S
Project Start
1994-08-01
Project End
2002-03-31
Budget Start
2001-01-01
Budget End
2002-03-31
Support Year
7
Fiscal Year
2000
Total Cost
$93,600
Indirect Cost
Name
University of Louisville
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
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