Molecular Mechanisms of Rpe Phagocytosis - Role of CD36 - Roy Silverstein

Abstract

Funding Agency

Agency: National Institute of Health (NIH)
Institute: National Eye Institute (NEI)
Type: Research Project (R01)
Project #: 5R01EY010967-02
Application #: 2165170
Study Section: Visual Sciences C Study Section (VISC)

Project Start: 1995-05-01
Project End: 1999-04-30
Budget Start: 1996-05-01
Budget End: 1997-04-30
Support Year: 2
Fiscal Year: 1996
Total Cost
Indirect Cost

Institution

Name: Weill Medical College of Cornell University
Department: Internal Medicine/Medicine
Type: Schools of Medicine
DUNS #: 201373169

City: New York
State: NY
Country: United States
Zip Code: 10065

Related projects


NIH 2002 R01 EY	Molecular Mechanisms of Rpe Phagocytosis - Role of CD36 Silverstein, Roy L. / Weill Medical College of Cornell University	$283,746
NIH 2001 R01 EY	Molecular Mechanisms of Rpe Phagocytosis - Role of CD36 Silverstein, Roy L. / Weill Medical College of Cornell University	$275,481
NIH 2000 R01 EY	Molecular Mechanisms of Rpe Phagocytosis - Role of CD36 Silverstein, Roy L. / Weill Medical College of Cornell University	$267,458
NIH 1999 R01 EY	Molecular Mechanisms of Rpe Phagocytosis - Role of CD36 Silverstein, Roy L. / Weill Medical College of Cornell University
NIH 1998 R01 EY	Molecular Mechanisms of Rpe Phagocytosis - Role of CD36 Silverstein, Roy L. / Weill Medical College of Cornell University
NIH 1997 R01 EY	Molecular Mechanisms of Rpe Phagocytosis - Role of CD36 Silverstein, Roy L. / Weill Medical College of Cornell University
NIH 1996 R01 EY	Molecular Mechanisms of Rpe Phagocytosis - Role of CD36 Silverstein, Roy L. / Weill Medical College of Cornell University
NIH 1995 R01 EY	Molecular Mechanisms of Rpe Phagocytosis - Role of CD36 Silverstein, Roy L. / Weill Medical College of Cornell University

Publications

Sun, Mingjiang; Finnemann, Silvia C; Febbraio, Maria et al. (2006) Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions. J Biol Chem 281:4222-30

Febbraio, M; Hajjar, D P; Silverstein, R L (2001) CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. J Clin Invest 108:785-91

Finnemann, S C; Silverstein, R L (2001) Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium. J Exp Med 194:1289-98

Albert, M L; Pearce, S F; Francisco, L M et al. (1998) Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med 188:1359-68

Sparrow, J R; Ryeom, S W; Abumrad, N A et al. (1997) CD36 expression is altered in retinal pigment epithelial cells of the RCS rat. Exp Eye Res 64:45-56

Ryeom, S W; Silverstein, R L; Scotto, A et al. (1996) Binding of anionic phospholipids to retinal pigment epithelium may be mediated by the scavenger receptor CD36. J Biol Chem 271:20536-9

Ryeom, S W; Sparrow, J R; Silverstein, R L (1996) CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium. J Cell Sci 109 ( Pt 2):387-95

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