Behavioral plasticity is widely thought to require both protein synthesis and protein turnover. Although several studies indicate that protein homeostasis is tightly regulated and that new protein synthesis can have rapid effects on synaptic plasticity, aside from a few well-studied examples, the identification and function of newly- synthesized proteins is still limited. We propose multidisciplinary experiments using state of the art proteomics to identify newly-synthesized proteins induced in response to conditioning stimuli, to probe the time course for protein synthesis in conditioning- induced behavioral plasticity of a visuomotor task, and to test whether the rapid synthesis of key proteins plays a role in plasticity. Results from the proposed experiments will illuminate novel mechanisms of brain plasticity and may have bearing on treatments for neurodevelopmental disorders, such as autism spectrum disorders, or neurorepair following injury.

Public Health Relevance

Protein synthesis is thought to be required for behavioral plasticity. We propose experiments to identify proteins that are newly synthesized during behavioral training and to determine their function in the brain.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY011261-20
Application #
8868998
Study Section
Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section (SPC)
Program Officer
Greenwell, Thomas
Project Start
1995-12-06
Project End
2019-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
20
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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