This is a collaborative multi-disciplinary program involving investigators at the Massachusetts Institute of Technology and the New England Eye Center. Optical Coherence Tomography (OCT) is an emerging technology for ophthalmic performance that can perform non-contact, non-invasive real time cross sectional imaging of the retina and the anterior eye. Standard ophthalmic OCT has a 10 micron axial resolution, ten times higher than conventional ultrasound. Our objective is to develop new OCT technology, which achieves a quantum leap in performance over current ophthalmic OCT and to demonstrate this technology for the early diagnosis and monitoring of disease of the retina and anterior eye. We will increase OCT axial image resolution by 5 to 10 times from 10 microns to about 1-2 microns. And also develop multi-wavelength, spectroscopic OCT techniques to improve differentiation of morphology and permit micron scale functional imaging. Our hypothesis is that these advances will dramatically enhance ability to image structural morphology such as intraretinal features, as well as improve the accuracy in reproducibility of morphometric measurements such as retinal thickness or nerve fiber layer thickness. We propose to: 1. Develop ultra high resolution OCT technology for imaging the retina and anterior eye. 2. Image transgenic retinal mouse models and cross sectional and longitudinal studies. 3. Perform cross sectional patient studies to investigate the capabilities of ultra-high resolution OCT for identifying micro-structural changes associated with posterior segment diseases. 4. Investigate ultra high resolution OCT for improving the accuracy of morphometric imaging of retinal thickness and nerve fiber layer thickness. 5. Investigate imaging structures in the anterior eye at the cellular level. 6. Perform preliminary clinical studies to investigate the ability of ultra high resolution OCT to identify ocular pathologies in the anterior eye segment. 7. Develop and demonstrate spectroscopic OCT techniques enabling spectrally resolved tomographic imaging on the micron scale. 8. Demonstrate spectroscopic OCT imaging of oxygen saturation in retinal and choroidal vasculature. 9. Perform preliminary clinical studies to assess the effectiveness of ultra high resolution structural, morphometric, or spectroscopic OCT imaging to diagnosis and monitor the progression of retinal disease. This proposal involves the development of new instrumentation which will have wide spread research and clinical applications as well as the development and validation of methods for the early diagnosis and monitoring of diseases including AMD, glaucoma, and diabetic retinopathy.
| Arya, Malvika; Rashad, Ramy; Sorour, Osama et al. (2018) Optical coherence tomography angiography (OCTA) flow speed mapping technology for retinal diseases. Expert Rev Med Devices :1-8 |
| Schirrmacher, Franziska; Köhler, Thomas; Endres, Jürgen et al. (2018) Temporal and volumetric denoising via quantile sparse image prior. Med Image Anal 48:131-146 |
| Liang, Kaicheng; Wang, Zhao; Ahsen, Osman O et al. (2018) Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo. Optica 5:36-43 |
| Wang, Bo; Lucy, Katie A; Schuman, Joel S et al. (2018) Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa. Sci Rep 8:7281 |
| Lee, Hsiang-Chieh; Ahsen, Osman O; Liu, Jonathan J et al. (2017) Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography. J Biomed Opt 22:76001 |
| Liang, Kaicheng; Ahsen, Osman O; Wang, Zhao et al. (2017) Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source. Opt Lett 42:3193-3196 |
| Sebrow, Dov B; Cunha de Souza, Eduardo; Belúcio Neto, José et al. (2017) MACROANEURYSMS ASSOCIATED WITH CONGENITAL RETINAL MACROVESSELS. Retin Cases Brief Rep : |
| Dong, Zachary M; Wollstein, Gadi; Wang, Bo et al. (2017) Adaptive optics optical coherence tomography in glaucoma. Prog Retin Eye Res 57:76-88 |
| Lavinsky, Fabio; Wollstein, Gadi; Tauber, Jenna et al. (2017) The Future of Imaging in Detecting Glaucoma Progression. Ophthalmology 124:S76-S82 |
| Lee, ByungKun; Novais, Eduardo A; Waheed, Nadia K et al. (2017) En Face Doppler Optical Coherence Tomography Measurement of Total Retinal Blood Flow in Diabetic Retinopathy and Diabetic Macular Edema. JAMA Ophthalmol 135:244-251 |
Showing the most recent 10 out of 300 publications
