Aim 1 defines the microsurgical anatomy of human extraocular muscle that is needed for erbium laser procedure development.
Aim 2 represents a design/development phase in adapting a commercial erbium laser for the purpose of selective weakening of extraocular muscle.
Aims 3 and 4 use a rabbit model to develop laser applications specific for the targeted removal of a longitudinal muscle strip and denervation of selected segments of extraocular muscle.
Aim 5 applies the targeted muscle compromise procedures developed in the rabbit to a subhuman primate model in which both muscle morphology and quantitative eye movement behavior can be tightly correlated.
Aim 6 represents human pilot studies needed for design of clinical trials for the therapy developed in this proposal.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
3R01EY012216-03S1
Application #
6555187
Study Section
Special Emphasis Panel (ZRG1 (03))
Program Officer
Hunter, Chyren
Project Start
1998-08-01
Project End
2002-11-30
Budget Start
2000-08-01
Budget End
2002-11-30
Support Year
3
Fiscal Year
2002
Total Cost
$106,254
Indirect Cost
Name
Smith-Kettlewell Eye Research Institute
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94115
Morad, Y; Kowal, L; Scott, A B (2005) Lateral rectus muscle disinsertion and reattachment to the lateral orbital wall. Br J Ophthalmol 89:983-5