Aim 1 defines the microsurgical anatomy of human extraocular muscle that is needed for erbium laser procedure development.
Aim 2 represents a design/development phase in adapting a commercial erbium laser for the purpose of selective weakening of extraocular muscle.
Aims 3 and 4 use a rabbit model to develop laser applications specific for the targeted removal of a longitudinal muscle strip and denervation of selected segments of extraocular muscle.
Aim 5 applies the targeted muscle compromise procedures developed in the rabbit to a subhuman primate model in which both muscle morphology and quantitative eye movement behavior can be tightly correlated.
Aim 6 represents human pilot studies needed for design of clinical trials for the therapy developed in this proposal.
| Morad, Y; Kowal, L; Scott, A B (2005) Lateral rectus muscle disinsertion and reattachment to the lateral orbital wall. Br J Ophthalmol 89:983-5 |
