This application focuses on the role of CD81 in the cellular response of the retina to injury. This group was the first to demonstrate that CD81 is expressed in the retina and that there is a significant up-regulation of the gene product following injury. The hypotheses is that TAPA is part of the molecular complex mediating contact inhibition for glial cells and retinal pigment epithelium (RPE). This application will address four questions regarding CD81 and the proliferative response of retinal cells: (1) whether CD81 regulates glial cell and RPE number during normal retinal development; (2) whether CD81 plays a role following injury; (3) whether the activation of CD81 down-regulates the proliferative response of retinal glia; and (4) what glial proteins associate with CD81 to regulate cell proliferation in the retina.
| Pan, Ye; Brown, Christina; Wang, XiangDi et al. (2007) The developmental regulation of CD81 in the rat retina. Mol Vis 13:181-9 |
| Liu, Li; Geisert, Eldon E; Frankfurter, Anthony et al. (2007) A transgenic mouse class-III beta tubulin reporter using yellow fluorescent protein. Genesis 45:560-9 |
| Vazquez-Chona, Felix R; Khan, Amna N; Chan, Chun K et al. (2005) Genetic networks controlling retinal injury. Mol Vis 11:958-70 |
| Vazquez-Chona, Felix; Song, Bong K; Geisert Jr, Eldon E (2004) Temporal changes in gene expression after injury in the rat retina. Invest Ophthalmol Vis Sci 45:2737-46 |
| Song, Bong K; Levy, Shoshana; Geisert Jr, Eldon E (2004) Increased density of retinal pigment epithelium in cd81-/- mice. J Cell Biochem 92:1160-70 |
| Timmons, S D; Geisert, E; Stewart, A E et al. (2004) alpha2-Adrenergic receptor-mediated modulation of calcium current in neocortical pyramidal neurons. Brain Res 1014:184-96 |
| Song, Bong Keun; Geisert, Grace R; Vazquez-Chona, Felix et al. (2003) Temporal regulation of CD81 following retinal injury in the rat. Neurosci Lett 338:29-32 |
| Rogojina, Anna T; Orr, William E; Song, Bong K et al. (2003) Comparing the use of Affymetrix to spotted oligonucleotide microarrays using two retinal pigment epithelium cell lines. Mol Vis 9:482-96 |
| Wagner, Carl E; Mohler, Michael L; Kang, Gyong Suk et al. (2003) Synthesis of 1-boraadamantaneamine derivatives with selective astrocyte vs C6 glioma antiproliferative activity. A novel class of anti-hepatitis C agents with potential to bind CD81. J Med Chem 46:2823-33 |
| Geisert Jr, Eldon E; Williams, Robert W; Geisert, Grace R et al. (2002) Increased brain size and glial cell number in CD81-null mice. J Comp Neurol 453:22-32 |
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