The goal of the proposed research is to understand the roles of centrifugal input in vertebrate retinas. In all vertebrates (include humans), the retinas receive centrifugal input from the brain. In fish, the centrifugal input originates from the terminalis nerve (TN) in the olfactory bulb. In the retina, the TN fibers synapse onto dopaminergic interplexiform cells (DA-IPCs). The proposed research will investigate the biological roles of the centrifugal pathway in visual system functions. Specifically, we will determine the physiological properties of the TN cells, the effects of centrifugal input in vision, and the genetic mechanisms of the development of the centrifugal pathway. The results from the proposed research will shed light on the mechanisms of centrifugal modulation of visual sensitivity.

Public Health Relevance

The vertebrate retinas receive centrifugal input from the brain. We will study the biological roles of the centrifugal input in retinal function using the zebrafish models. The results will shed light on the mechanisms of centrifugal visual modulation in other vertebrate species, including mammals.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY013147-08
Application #
7895523
Study Section
Biology and Diseases of the Posterior Eye Study Section (BDPE)
Program Officer
Greenwell, Thomas
Project Start
2000-07-01
Project End
2012-07-31
Budget Start
2010-08-01
Budget End
2012-07-31
Support Year
8
Fiscal Year
2010
Total Cost
$375,000
Indirect Cost
Name
University of Notre Dame
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
824910376
City
Notre Dame
State
IN
Country
United States
Zip Code
46556
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