Abstract

The goal of the proposed research is to understand the roles of centrifugal input in vertebrate retinas. In all vertebrates (include humans), the retinas receive centrifugal input from the brain. In fish, the centrifugal input originates from the terminalis nerve (TN) in the olfactory bulb. In the retina, the TN fibers synapse onto dopaminergic interplexiform cells (DA-IPCs). The proposed research will investigate the biological roles of the centrifugal pathway in visual system functions. Specifically, we will determine the physiological properties of the TN cells, the effects of centrifugal input in vision, and the genetic mechanisms of the development of the centrifugal pathway. The results from the proposed research will shed light on the mechanisms of centrifugal modulation of visual sensitivity.

Public Health Relevance

The vertebrate retinas receive centrifugal input from the brain. We will study the biological roles of the centrifugal input in retinal function using the zebrafish models. The results will shed light on the mechanisms of centrifugal visual modulation in other vertebrate species, including mammals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY013147-08
Application #
7895523
Study Section
Biology and Diseases of the Posterior Eye Study Section (BDPE)
Program Officer
Greenwell, Thomas
Project Start
2000-07-01
Project End
2012-07-31
Budget Start
2010-08-01
Budget End
2012-07-31
Support Year
8
Fiscal Year
2010
Total Cost
$375,000
Indirect Cost

  Institution

Name
University of Notre Dame
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
824910376
City
Notre Dame
State
IN
Country
United States
Zip Code
46556

  Publications

Sun, Lei; Li, Ping; Carr, Aprell L et al. (2014) Transcription of the SCL/TAL1 interrupting Locus (Stil) is required for cell proliferation in adult Zebrafish Retinas. J Biol Chem 289:6934-40
Xu, Jia-Xi; Si, Man; Zhang, Hui-Ran et al. (2014) Phosphoinositide kinases play key roles in norepinephrine- and angiotensin II-induced increase in phosphatidylinositol 4,5-bisphosphate and modulation of cardiac function. J Biol Chem 289:6941-8
Sun, Lei; Carr, Aprell L; Li, Ping et al. (2014) Characterization of the human oncogene SCL/TAL1 interrupting locus (Stil) mediated Sonic hedgehog (Shh) signaling transduction in proliferating mammalian dopaminergic neurons. Biochem Biophys Res Commun 449:444-8
Carr, Aprell L; Sun, Lei; Lee, Eric et al. (2014) The human oncogene SCL/TAL1 interrupting locus is required for mammalian dopaminergic cell proliferation through the Sonic hedgehog pathway. Cell Signal 26:306-12
Li, Jingling; Li, Ping; Carr, Aprell et al. (2013) Functional expression of SCL/TAL1 interrupting locus (Stil) protects retinal dopaminergic cells from neurotoxin-induced degeneration. J Biol Chem 288:886-93
Li, Xinle; Montgomery, Jake; Cheng, Wesley et al. (2012) Pineal photoreceptor cells are required for maintaining the circadian rhythms of behavioral visual sensitivity in zebrafish. PLoS One 7:e40508
Ye, Qijun; Chen, Dongyan; Xi, Yang et al. (2012) Effects of light illumination and the expression of wee1 on tissue regeneration in adult zebrafish. Biochem Biophys Res Commun 428:132-6
Shao, Jinping; Chen, Dongyan; Ye, Qijun et al. (2011) Tissue regeneration after injury in adult zebrafish: the regenerative potential of the caudal fin. Dev Dyn 240:1271-7
Huang, Luoxiu; Li, Lei (2011) Characterization of voltage-activated ionic currents in the GnRH-containing terminalis nerve in transgenic zebrafish. Brain Res 1367:43-9
Wang, Xiaokai; Huang, Luoxiu; Li, Yue et al. (2011) Characterization of GFP-tagged GnRH-containing terminalis neurons in transgenic zebrafish. J Cell Physiol 226:608-15

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