This proposal will analyze how the primate retina represents motion information, and how this information compares with psychophysical performance in human observers and with published studies on the receptive field properties of cortical area MT. The experiments will involve multielectrode recordings from an in vitro preparation of macaque retina.
Aim 1. The P.I. will look at how the accuracy of motion discrimination is represented in the retina, how this might be represented by neural ensembles, and how the M and P ganglion cells might differ in their individual accuracy.
Aim 2. This goes farther into the question of the role of spike timing in generating psychophysical performance.
Aim 3. Does retinal signaling limit accuracy of behavioral and cortical motion sensing? This part will include psychophysical studies as well as correlation with recordings in MT obtained from other investigators.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
Project #
Application #
Study Section
Visual Sciences B Study Section (VISB)
Program Officer
Oberdorfer, Michael
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Salk Institute for Biological Studies
La Jolla
United States
Zip Code
Ala-Laurila, Petri; Greschner, Martin; Chichilnisky, E J et al. (2011) Cone photoreceptor contributions to noise and correlations in the retinal output. Nat Neurosci 14:1309-16
Greschner, Martin; Shlens, Jonathon; Bakolitsa, Constantina et al. (2011) Correlated firing among major ganglion cell types in primate retina. J Physiol 589:75-86
Conway, Bevil R; Chatterjee, Soumya; Field, Greg D et al. (2010) Advances in color science: from retina to behavior. J Neurosci 30:14955-63
Field, Greg D; Gauthier, Jeffrey L; Sher, Alexander et al. (2010) Functional connectivity in the retina at the resolution of photoreceptors. Nature 467:673-7
Field, Greg D; Greschner, Martin; Gauthier, Jeffrey L et al. (2009) High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina. Nat Neurosci 12:1159-64
Weaver, Matt S; Toida, Natalie; Sage, E Helene (2007) Expression of integrin-linked kinase in the murine lens is consistent with its role in epithelial-mesenchymal transition of lens epithelial cells in vitro. Mol Vis 13:707-18
Shlens, Jonathon; Field, Greg D; Gauthier, Jeffrey L et al. (2006) The structure of multi-neuron firing patterns in primate retina. J Neurosci 26:8254-66
Weaver, Matt S; Sage, E Helene; Yan, Qi (2006) Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitro. J Cell Biochem 97:423-32
Sekirnjak, Chris; Hottowy, Pawel; Sher, Alexander et al. (2006) Electrical stimulation of mammalian retinal ganglion cells with multielectrode arrays. J Neurophysiol 95:3311-27
Kennel, Matthew B; Shlens, Jonathon; Abarbanel, Henry D I et al. (2005) Estimating entropy rates with Bayesian confidence intervals. Neural Comput 17:1531-76

Showing the most recent 10 out of 16 publications