Behavior relies on the reliable interpretation of sensory information and the flexible association of that information with actions. It therefore depends on the both the accurate encoding of information by sensory neurons and the appropriate decoding of these sensory signals according to task constraints. In circumstances involving rapid changes in the sensory environment, the speed of these processes can be of paramount importance: an inability to quickly respond to a looming threat can be fatal. Evidence acquired in the previous grant submission demonstrates that the activity of single neurons over tens of milliseconds can accurately and precisely encode motion information. The same brief periods of activity were also strongly predictive of behavioral choice when animals were engaged in a natural foveation task, and therefore potentially play a pivotal role in rapid decision making. The proposed experiments will explore how such precision is distributed among neural populations and how it is altered by training or task demands. Animals will be trained in tasks requiring the rapid analysis of motion information. Simultaneous recording of neuronal activity and behavior will be analyzed to infer the precision and reliability of sensory signals and their influence on behavioral choice. In the first specific aim, the distribution of reliable sensory information over a cortical population will be investigated. In the first experiment, nearby neurons will be simultaneously activated by a motion stimulus in order to examine how activity correlations might improve or degrade sensory information and its association with behavioral outcome. In the second experiment, the stimulus dependence of precision and reliability will be used to infer how these factors vary across a broad population of activated neurons. In the second specific aim, recordings of individual neurons will be made during the acquisition of proficiency in rapid motion detection to study the extent to which this precision is learned. In the third specific aim, stimulus and probability manipulations will be used to reveal the specific task parameters responsible for such precise neuronal activity. Because all of these tasks are highly challenging, they will help reveal the underlying constraints on the accuracy and speed of decision making. By simultaneously addressing the reliability and precision of sensory encoding and decoding within the brain, these studies could also provide valuable information for the development of effective neural interfaces for prosthetics.

Public Health Relevance

Decisions based on small epochs of perceptual information are often of life-or-death importance not only in nature but every time we cross a busy intersection or navigate a busy highway. However, no existing model is able to explain how our brains are able to rapidly and reliably process brief amounts of information and subsequently plan and execute appropriate actions on the basis on that information. This goal of this proposal is to reveal the physiological basis of such capabilities by investigating how neural activity in a specific brain area is able to precisely represent visual information and influence behaviors during the course of rapid decision making.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Central Visual Processing Study Section (CVP)
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Steinmetz, Michael A
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University of Minnesota Twin Cities
Schools of Medicine
United States
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Weiner, Katherine F; Ghose, Geoffrey M (2015) Population coding in area V4 during rapid shape detections. J Neurophysiol 113:3021-34
Ghose, Geoffrey M (2015) Vision and vigilance on the go. Trends Cogn Sci 19:115-6
Warren, Scott G; Yacoub, Essa; Ghose, Geoffrey M (2014) Featural and temporal attention selectively enhance task-appropriate representations in human primary visual cortex. Nat Commun 5:5643
Harrison, Ian T; Weiner, Katherine F; Ghose, Geoffrey M (2013) Inattention blindness to motion in middle temporal area. J Neurosci 33:8396-410
Schneider, Blaine A; Ghose, Geoffrey M (2012) Temporal production signals in parietal cortex. PLoS Biol 10:e1001413
Ghose, Geoffrey M; Bearl, David W (2010) Attention directed by expectations enhances receptive fields in cortical area MT. Vision Res 50:441-51
Ghose, Geoffrey M; Harrison, Ian T (2009) Temporal precision of neuronal information in a rapid perceptual judgment. J Neurophysiol 101:1480-93
Ghose, Geoffrey M (2009) Attentional modulation of visual responses by flexible input gain. J Neurophysiol 101:2089-106
Ghose, Geoffrey M; Maunsell, John H R (2008) Spatial summation can explain the attentional modulation of neuronal responses to multiple stimuli in area V4. J Neurosci 28:5115-26
Ghose, Geoffrey M (2006) Strategies optimize the detection of motion transients. J Vis 6:429-40