The perception of a visual """"""""figure"""""""" often relies upon the overall spatial arrangement of its local elements. The global attributes of a visual stimulus can affect the response of visual cortical neurons to the local attributes of the stimulus. Thus, the response of early visual cortical neurons to stimuli within their classical receptive field (cRF) can be modulated by contextual stimuli outside their cR. Fast interactions beyond the cRF are needed to mediate these modulatory effects. The long-term goal of this proposal is to disentangle the relative contributions of inter-areal (feedforward and feedback) and intra-areal horizontal corticocortical connections to these global-to-local interactions in early visual cortex. The neural circuitry and mechanisms involved are likely to be the cornerstone of contour integration, and figure-ground segregation. Thus, results from these studies ultimately will help understanding the neural substrates for higher visual cortical processing and perception in primate and man. The work described in this application is designed to investigate how the spatial extent and functional specificity of intra-areal and inter-areal connections in cortical areas V1, V2 and V3 relates to the spatial scale and functional specificity of single V1, V2 and V3 neurons responses to stimuli within and beyond their cRF. We will determine the visuotopic extent of the intra- and inter-areal fields of connections labeled by small tracer injections delivered to specific functional compartments of areas V2 and V3 in the marmoset monkey. The visuotopic scale of each connectional system will then be compared to the spatial dimensions of single V1, V2 and V3 neurons' cRF and non-cRF responses, determined by single unit recordings. We will use combined optical imaging and tracer injections to determine whether each of the connectional system is organized in a patterned or diffuse fashion, and how specific connectional patterns relate to the underlying feature maps and functional compartments of early visual cortical areas.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY015262-03
Application #
7077657
Study Section
Central Visual Processing Study Section (CVP)
Program Officer
Oberdorfer, Michael
Project Start
2004-08-01
Project End
2009-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
3
Fiscal Year
2006
Total Cost
$364,967
Indirect Cost
Name
University of Utah
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Kingdom, Frederick A A; Angelucci, Alessandra; Clifford, Colin W G (2014) Special issue: The function of contextual modulation. Vision Res 104:1-2
Nurminen, Lauri; Angelucci, Alessandra (2014) Multiple components of surround modulation in primary visual cortex: multiple neural circuits with multiple functions? Vision Res 104:47-56
Jeffs, Janelle; Federer, Frederick; Ichida, Jennifer M et al. (2013) High-resolution mapping of anatomical connections in marmoset extrastriate cortex reveals a complete representation of the visual field bordering dorsal V2. Cereb Cortex 23:1126-47
Shushruth, S; Nurminen, Lauri; Bijanzadeh, Maryam et al. (2013) Different orientation tuning of near- and far-surround suppression in macaque primary visual cortex mirrors their tuning in human perception. J Neurosci 33:106-19
Shushruth, S; Mangapathy, Pradeep; Ichida, Jennifer M et al. (2012) Strong recurrent networks compute the orientation tuning of surround modulation in the primate primary visual cortex. J Neurosci 32:308-21
Schwabe, Lars; Ichida, Jennifer M; Shushruth, S et al. (2010) Contrast-dependence of surround suppression in Macaque V1: experimental testing of a recurrent network model. Neuroimage 52:777-92
Federer, Frederick; Ichida, Jennifer M; Jeffs, Janelle et al. (2009) Four projection streams from primate V1 to the cytochrome oxidase stripes of V2. J Neurosci 29:15455-71
Jeffs, Janelle; Ichida, Jennifer M; Federer, Frederick et al. (2009) Anatomical evidence for classical and extra-classical receptive field completion across the discontinuous horizontal meridian representation of primate area V2. Cereb Cortex 19:963-81
Shushruth, S; Ichida, Jennifer M; Levitt, Jonathan B et al. (2009) Comparison of spatial summation properties of neurons in macaque V1 and V2. J Neurophysiol 102:2069-83
Ichida, Jennifer M; Schwabe, Lars; Bressloff, Paul C et al. (2007) Response facilitation from the ""suppressive"" receptive field surround of macaque V1 neurons. J Neurophysiol 98:2168-81

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