The broad goals of this project are to understand the scope and sophistication of retinal processing. This project builds on preliminary data showing that the retina can quickly learn simple patterns in the visual stimulus, such as a temporal periodicity or a smooth motion trajectory, so that a subset of ganglion cells fires selectively after a violation of the predicted pattern. Such cognitively loaded phenomena are typically thought to arise only in the cortex, but observing them in the retina both enhances our appreciation of the computational capabilities of neural circuits and also allows us to explore the mechanisms responsible, a task that often cannot be carried out in more central neural circuits.
The Specific Aims are: 1) exploring the properties of retinal pattern detection with multi-electrode array experiments;2) studying the mechanisms of temporal pattern detection using designed stimuli, pharmacology, and computational models;3) studying the properties of and mechanisms behind the retina's ability to detect motion discontinuities. A detailed knowledge of how the population of retinal ganglion cells represents the visual world is of fundamental interest to neuroscience and is also important for guiding the development of a retinal prosthesis to restore vision successfully.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY017934-05
Application #
8136080
Study Section
Biology and Diseases of the Posterior Eye Study Section (BDPE)
Program Officer
Greenwell, Thomas
Project Start
2007-09-30
Project End
2014-08-31
Budget Start
2011-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2011
Total Cost
$364,388
Indirect Cost
Name
Princeton University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
002484665
City
Princeton
State
NJ
Country
United States
Zip Code
08544
Marre, Olivier; Botella-Soler, Vicente; Simmons, Kristina D et al. (2015) High Accuracy Decoding of Dynamical Motion from a Large Retinal Population. PLoS Comput Biol 11:e1004304
Chen, Eric Y; Chou, Janice; Park, Jeongsook et al. (2014) The neural circuit mechanisms underlying the retinal response to motion reversal. J Neurosci 34:15557-75
Aljadeff, Johnatan; Segev, Ronen; Berry 2nd, Michael J et al. (2013) Spike triggered covariance in strongly correlated gaussian stimuli. PLoS Comput Biol 9:e1003206
Chen, Eric Y; Marre, Olivier; Fisher, Clark et al. (2013) Alert response to motion onset in the retina. J Neurosci 33:120-32
Kaardal, Joel; Fitzgerald, Jeffrey D; Berry 2nd, Michael J et al. (2013) Identifying functional bases for multidimensional neural computations. Neural Comput 25:1870-90
Vasquez, J C; Marre, O; Palacios, A G et al. (2012) Gibbs distribution analysis of temporal correlations structure in retina ganglion cells. J Physiol Paris 106:120-7
Marre, Olivier; Amodei, Dario; Deshmukh, Nikhil et al. (2012) Mapping a complete neural population in the retina. J Neurosci 32:14859-73
Soo, Frederick S; Schwartz, Gregory W; Sadeghi, Kolia et al. (2011) Fine spatial information represented in a population of retinal ganglion cells. J Neurosci 31:2145-55
Gao, Juan; Schwartz, Greg; Berry 2nd, Michael J et al. (2009) An oscillatory circuit underlying the detection of disruptions in temporally-periodic patterns. Network 20:106-35
Schwartz, Greg; Berry 2nd, Michael J (2008) Sophisticated temporal pattern recognition in retinal ganglion cells. J Neurophysiol 99:1787-98