A hallmark of primary visual cortex is its organization into maps of visual space, orientation and ocular dominance. Despite remarkable advances in our ability to measure the structure of cortical maps and their mutual relationships, many important questions remain unanswered. How do these maps develop? Why are maps missing in some species? What role do maps play, if any, in cortical computation? The central goal of our research is to seek answers to these fundamental questions of cortical development, organization and function that have eluded us for decades. Our working hypothesis is that the blueprint for the formation of simple-cell receptive fields and orientation maps in primary visual cortex is encoded in the spatial layout of retinal ganglion cell (RGC) mosaics. To test the idea we will analyze the spatial statistics of RGC mosaics, reconstruct the retinal input to given orientation domains, and test the micro-organization of cortical maps. If the these ideas are confirmed, they can offer a definitive account for the origin of orientation maps in primary visua cortex and, more broadly, profoundly influence the way we conceive of cortical maps, their development and function.

Public Health Relevance

We do not yet know how the brain develops the myriad of connections upon which normal brain activity and behavior depend upon. To better understand developmental disorders of the central nervous system, we need to elucidate how the brain wires itself under normal conditions. The proposed studies address this important question for the early stages of visual processing by investigating how the eyes establish connections to the visual cortex.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY018322-08
Application #
8889680
Study Section
Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section (SPC)
Program Officer
Flanders, Martha C
Project Start
2007-09-01
Project End
2016-05-31
Budget Start
2015-06-01
Budget End
2016-05-31
Support Year
8
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Neurosciences
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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