Inferotemporal cortex (IT) plays a crucial role in object vision as indicated by the fact that injury to it results in profound recognition deficits. The role played by IT in object recognition has been elucidated by research carried out over several decades in macaque monkeys. This has indicated that neurons in IT are pattern selective. Each neuron responds to certain complex images and not others. To gain an understanding of the nature of neuronal pattern selectivity in IT - and hence to cast light on the nature of the neural machinery that underlies visual pattern recognition - is the aim of experiments described in this proposal. Three series of experiments will be carried out. The approach in each case will be to measure the responses of neurons to displays consisting of discrete parts that can be manipulated independently so as to determine how the response to the whole is built up from the responses to the parts. Series 1 will ask whether IT neurons as a population represent, in a dimensionally reduced code, a family of shapes consisting of joined linear segments and having roughly the complexity of alphanumeric characters. Series 2 will ask whether neurons in IT are selective for the arrangement of elements in an image and, if so, whether selectivity is invariant across changes in size and location. Series 3 will ask how neuronal activity in IT represents displays consisting of items in an array, including words and hierarchical stimuli.

National Institute of Health (NIH)
National Eye Institute (NEI)
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Central Visual Processing Study Section (CVP)
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Steinmetz, Michael A
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Carnegie-Mellon University
Schools of Arts and Sciences
United States
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Ramachandran, Suchitra; Meyer, Travis; Olson, Carl R (2016) Prediction suppression in monkey inferotemporal cortex depends on the conditional probability between images. J Neurophysiol 115:355-62
Crowder, Erin A; Olson, Carl R (2015) Macaque monkeys experience visual crowding. J Vis 15:14
Berdyyeva, Tamara K; Olson, Carl R (2014) Intracortical microstimulation of supplementary eye field impairs ability of monkeys to make serially ordered saccades. J Neurophysiol 111:1529-40
Meyer, Travis; Ramachandran, Suchitra; Olson, Carl R (2014) Statistical learning of serial visual transitions by neurons in monkey inferotemporal cortex. J Neurosci 34:9332-7
Leathers, Marvin L; Olson, Carl R (2012) In monkeys making value-based decisions, LIP neurons encode cue salience and not action value. Science 338:132-5
Meyer, Travis; Olson, Carl R (2011) Statistical learning of visual transitions in monkey inferotemporal cortex. Proc Natl Acad Sci U S A 108:19401-6
Berdyyeva, Tamara K; Olson, Carl R (2011) Relation of ordinal position signals to the expectation of reward and passage of time in four areas of the macaque frontal cortex. J Neurophysiol 105:2547-59
Berdyyeva, Tamara K; Olson, Carl R (2010) Rank signals in four areas of macaque frontal cortex during selection of actions and objects in serial order. J Neurophysiol 104:141-59
Kim, Sung Soo; Sripati, Arun P; Bensmaia, Sliman J (2010) Predicting the timing of spikes evoked by tactile stimulation of the hand. J Neurophysiol 104:1484-96
Sripati, Arun P; Olson, Carl R (2010) Global image dissimilarity in macaque inferotemporal cortex predicts human visual search efficiency. J Neurosci 30:1258-69

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