Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY018720-03
Application #
7677307
Study Section
Biophysics of Neural Systems Study Section (BPNS)
Program Officer
Mariani, Andrew P
Project Start
2007-09-01
Project End
2012-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
3
Fiscal Year
2009
Total Cost
$353,250
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Pharmacology
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Rivoire, Olivier; Reynolds, Kimberly A; Ranganathan, Rama (2016) Evolution-Based Functional Decomposition of Proteins. PLoS Comput Biol 12:e1004817
Stiffler, Michael A; Subramanian, Subu K; Salinas, Victor H et al. (2016) A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing. J Vis Exp :
Raman, Arjun S; White, K Ian; Ranganathan, Rama (2016) Origins of Allostery and Evolvability in Proteins: A Case Study. Cell 166:468-480
Stiffler, Michael A; Hekstra, Doeke R; Ranganathan, Rama (2015) Evolvability as a function of purifying selection in TEM-1 ?-lactamase. Cell 160:882-892
Reynolds, Kimberly A; Russ, William P; Socolich, Michael et al. (2013) Evolution-based design of proteins. Methods Enzymol 523:213-35
McLaughlin Jr, Richard N; Poelwijk, Frank J; Raman, Arjun et al. (2012) The spatial architecture of protein function and adaptation. Nature 491:138-42
Reynolds, Kimberly A; McLaughlin, Richard N; Ranganathan, Rama (2011) Hot spots for allosteric regulation on protein surfaces. Cell 147:1564-75
Halabi, Najeeb; Rivoire, Olivier; Leibler, Stanislas et al. (2009) Protein sectors: evolutionary units of three-dimensional structure. Cell 138:774-86