Adaptation of saccadic eye movements is necessary so that saccade accuracy can be maintained throughout life despite the changes caused by development, aging and trauma. The long-term objective of this grant is to study the possible role of the oculomotor vermis (OMV) of the cerebellum in the adaptation process. We will approach this objective with 3 sets of experiments. In the first, we will inactivate the OMV pharmacologically and determine the deficit in the behavioral adaptation of saccades to an intra-saccadic target step, which causes saccades to appear inaccurate. In the second, we will examine the behavior of simple spike activity in the Purkinje cells of the oculomotor vermis to determine how it changes during this behavioral adaptation. Finally, we will activate the putative error signal pathway that drives adaptation by stimulating the superior colliculus, which is the likely source of the error-related climbing fiber activity to the OMV. Because of the similarities of simian and human saccadic eye movement behavior, the results of this project should have considerable relevance in the diagnosis, treatment and rehabilitation of patients with saccadic eye movement disorders.

Public Health Relevance

This proposal studies the brain mechanisms of saccadic eye movement adaptation. The results of this project are relevance in the diagnostics, treatment and rehabilitation of patients with saccadic eye movement disorders.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY019258-04
Application #
8247848
Study Section
Sensorimotor Integration Study Section (SMI)
Program Officer
Araj, Houmam H
Project Start
2009-04-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
4
Fiscal Year
2012
Total Cost
$415,800
Indirect Cost
$178,200
Name
University of Washington
Department
Physiology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Kojima, Yoshiko; Soetedjo, Robijanto (2018) Elimination of the error signal in the superior colliculus impairs saccade motor learning. Proc Natl Acad Sci U S A 115:E8987-E8995
Soetedjo, Robijanto (2018) Signals driving the adaptation of saccades that require spatial updating. J Neurophysiol 120:525-538
Herzfeld, David J; Kojima, Yoshiko; Soetedjo, Robijanto et al. (2018) Encoding of error and learning to correct that error by the Purkinje cells of the cerebellum. Nat Neurosci 21:736-743
Kojima, Yoshiko; Soetedjo, Robijanto (2017) Selective reward affects the rate of saccade adaptation. Neuroscience 355:113-125
Galvan, Adriana; Stauffer, William R; Acker, Leah et al. (2017) Nonhuman Primate Optogenetics: Recent Advances and Future Directions. J Neurosci 37:10894-10903
Kojima, Yoshiko; Soetedjo, Robijanto (2017) Change in sensitivity to visual error in superior colliculus during saccade adaptation. Sci Rep 7:9566
El-Shamayleh, Yasmine; Kojima, Yoshiko; Soetedjo, Robijanto et al. (2017) Selective Optogenetic Control of Purkinje Cells in Monkey Cerebellum. Neuron 95:51-62.e4
Herzfeld, David J; Kojima, Yoshiko; Soetedjo, Robijanto et al. (2015) Encoding of action by the Purkinje cells of the cerebellum. Nature 526:439-42
Kojima, Yoshiko; Fuchs, Albert F; Soetedjo, Robijanto (2015) Adaptation and adaptation transfer characteristics of five different saccade types in the monkey. J Neurophysiol 114:125-37
Kojima, Yoshiko; Robinson, Farrel R; Soetedjo, Robijanto (2014) Cerebellar fastigial nucleus influence on ipsilateral abducens activity during saccades. J Neurophysiol 111:1553-63

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