Visual information entering the brain is constantly changing. Its interpretation depends on the observers' goals, and on cognitive states that also change in response to current and previous visual input. Yet most of our knowledge of vision deals with spatial vision and spatial attention, and most existing computational models of vision and visual attention are static; they deal with stimuli that are isolated in time. This represents a critical barrier to a comprehensive theory of visual perception and attention. Temporal attention is the prioritized processing of a stimulus at a specific point in time, which can be voluntary, when a stimulus time can be anticipated, or involuntary, when attention is triggered automatically by a stimulus. The impact of temporal attention on perception and sensory cortical responses has been little investigated, despite its indispensable role in our understanding of a constantly changing environment. We propose to fill this critical gap in the cognitive neuroscience of attention. Our long-term goal is to develop a spatiotemporal theory of cortical computation, widely applicable in basic and translational research in perceptual and cognitive neuroscience. Our short-term goal is to investigate temporal attention to understand how perception is shaped by dynamic interactions between sensory input and attentional modulation, and how visual cortical processing underlies such interactions. We propose an innovative theoretical framework, which makes explicit how perception and attention interact across time (Aim 1). Two alternative dynamic models, early-gain vs. late-competition, in which temporal attention modulates different stages of processing, will be tested and constrained with data gathered with innovative experimental protocols, combining behavioral (psychophysics;
Aim 2) and neuroimaging (magnetoencephalography, MEG;
Aim 3) methods. Because orientation processing is well-characterized psychophysically and neurophysiologically in a static setting, we will use orientation discrimination and estimation tasks to determine the dynamic interactions between perception and attention. The empirical results will significantly advance our understanding of the time-course, perceptual consequences, resource limitations, and underlying neural mechanisms of temporal attention, and will also distinguish between alternative models and constrain model parameters. By integrating theory with behavioral and neuroimaging data, we will characterize how temporal attention dynamically changes perception and neural responses. The proposed research is fully in line with the NEI mission. It investigates how temporal attention modulates brain processing of visual information and how neural activity relates to visual perception. Further, because dynamic attention allocation is a central function of the visual system, the proposed research in healthy observers will be readily applicable to translational research in special populations, and may advance our understanding of abnormalities in temporal processing and temporal attention that have been associated with personality traits, like impulsivity, and prevalent disorders such as ADHD, autism, visual neglect and dyslexia.

Public Health Relevance

Temporal attention is an important determinant of visual perception. This proposal will investigate the processes that contribute to changes in visual temporal attention over timescales relevant for ongoing natural vision. The experimental protocols and theoretical principles that we propose will be widely applicable in basic as well as translational research in perceptual and cognitive neuroscience, given that abnormalities in temporal processing and temporal attention have been associated with personality traits, like impulsivity, and prevalent disorders such as ADHD, autism, visual neglect and dyslexia.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Cognition and Perception Study Section (CP)
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Wiggs, Cheri
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New York University
Schools of Arts and Sciences
New York
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Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11
Jigo, Michael; Carrasco, Marisa (2018) Attention alters spatial resolution by modulating second-order processing. J Vis 18:2
Cutrone, Elizabeth K; Heeger, David J; Carrasco, Marisa (2018) On spatial attention and its field size on the repulsion effect. J Vis 18:8
Dugué, Laura; Merriam, Elisha P; Heeger, David J et al. (2018) Specific Visual Subregions of TPJ Mediate Reorienting of Spatial Attention. Cereb Cortex 28:2375-2390
Denison, Rachel N; Heeger, David J; Carrasco, Marisa (2017) Attention flexibly trades off across points in time. Psychon Bull Rev 24:1142-1151
Li, Hsin-Hung; Rankin, James; Rinzel, John et al. (2017) Attention model of binocular rivalry. Proc Natl Acad Sci U S A 114:E6192-E6201
Poletti, Martina; Rucci, Michele; Carrasco, Marisa (2017) Selective attention within the foveola. Nat Neurosci 20:1413-1417
Li, Hsin-Hung; Barbot, Antoine; Carrasco, Marisa (2016) Saccade Preparation Reshapes Sensory Tuning. Curr Biol 26:1564-1570
Westrick, Zachary M; Heeger, David J; Landy, Michael S (2016) Pattern Adaptation and Normalization Reweighting. J Neurosci 36:9805-16
Wang, Helena X; Yuval-Greenberg, Shlomit; Heeger, David J (2016) Suppressive interactions underlying visually evoked fixational saccades. Vision Res 118:70-82

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