Binocular vision endows us with superior perceptual abilities in numerous tasks including those involving fine depth detection (stereopsis), figure/ground segmentation, space perception and visually guided actions. Having good binocular vision benefits athletes in their sports (e.g., basketball and volleyball) and professionals whose vocations demand acute depth perception (e.g., surgeons, dentists, machinists, and pilots). A common cause of poor binocular vision is excessive sensory eye dominance, a condition that is found in some people with clinically normal vision and in people with lazy eye (amblyopia). Sensory eye dominance could be due to an interocular imbalance of inhibition or integration, or both. This translational proposal employs a novel push-pull perceptual learning protocol to reduce sensory eye dominance due to interocular imbalance of inhibition and to improve stereopsis in adults. This approach rests on the hypothesis that the perceptual learning effect on sensory eye dominance is more effective when it targets the putative inhibitory network to restore the balance of excitatory and inhibitory interactions between the two eyes. The push-pull protocol works by forcing the weak eye to perceive its stimulus (push) as it simultaneously suppresses the strong eye's stimulus from being perceived (pull). This protocol is contrasted with a push-only protocol that solely stimulates the weak eye (push) while the strong eye is not stimulated. The push-pull protocol, and not the push-only protocol, results in significantly reduced sensory eye dominance and improved stereopsis in non-amblyopes and amblyopes. This proposal has three specific aims.
Aim 1 implements the push-pull protocol due to interocular imbalance of inhibition on a larger spectrum of amblyopic subjects (a heterogeneous group). The outcomes will provide a broader knowledge of how amblyopes respond to the perceptual learning protocol.
Aim 2 implements the push-pull protocol on non-amblyopes and improves on the utility and potency of the push-pull protocol by capitalizing on, and exploring, the basic underlying mechanisms related to attention, contrast gain control, channel bandwidths, etc.
Aim 3 investigates interocular imbalance of integration, identifies its underlying deficits using the multi-channel model of contrast gain control and incorporates the knowledge of interocular inhibition to develop a combined protocol to reduce sensory eye dominance. Reflecting the nature of this translational proposal, lessons learned from Aims 2 and 3 will be applied to Aim 1 and vice versa. The outcomes of this proposal, which focuses on restoring the interocular balance of excitatory and inhibitory interactions, will lead to improved binocular vision in people with normal vision who desire finer depth perception ability and in people with amblyopia. The long-term goal is to apply the knowledge gained into clinical application for the treatment of binocular visual disorders, including amblyopia. The lattr affects 2-3% of the population and if left untreated could lead to adverse personal and societal consequences.

Public Health Relevance

Binocular vision endows us with superior perceptual abilities in numerous tasks including those involving fine depth detection, surface segmentation (figure/ground), space perception and visually guided actions. However, binocular vision deteriorates when one has excessive sensory eye dominance, with the extreme case being associated with lazy eye (amblyopia). This project will further our understanding of visual information processing and adult cortical plasticity, and optimize a novel push-pull perceptual learning protocol to effectively reduce sensory eye dominance and improve binocular vision in amblyopes and non-amblyopes.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section (SPC)
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Araj, Houmam H
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Ohio State University
Schools of Optometry/Opht Tech
United States
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He, Zijiang J; Ooi, Teng Leng; Su, Yong R (2018) Perceptual mechanisms underlying amodal surface integration of 3-D stereoscopic stimuli. Vision Res 143:66-81
Han, Chao; He, Zijiang J; Ooi, Teng Leng (2018) On Sensory Eye Dominance Revealed by Binocular Integrative and Binocular Competitive Stimuli. Invest Ophthalmol Vis Sci 59:5140-5148
Zhou, Liu; Deng, Chenglong; Ooi, Teng Leng et al. (2016) Attention modulates perception of visual space. Nat Hum Behav 1:
Zhou, Liu; Ooi, Teng Leng; He, Zijiang J (2016) Intrinsic spatial knowledge about terrestrial ecology favors the tall for judging distance. Sci Adv 2:e1501070
Ooi, Teng Leng; He, Zijiang J (2015) Space perception of strabismic observers in the real world environment. Invest Ophthalmol Vis Sci 56:1761-8