Refractive error is the most common type of visual impairment in humans and is associated with an increased risk of developing other vision disorders, including primary open angle glaucoma. While an epidemiological association between these two traits is well established, the link is not well understood at a clinical, pathological, and mechanistic level. For this reason, investigating the role of refractive error in the etiology of primary open angle glaucoma can illuminate an important feature in the development of this common and complex vision disorder. This study will address the question of whether the mechanisms that underlie the link between refractive error and primary open-angle glaucoma operate directly through refractive error, or indirectly through shared effects, or both. For this purpose, we will conduct detailed genetic analyses that utilize a unique and powerful resource: the Kaiser Permanente Northern California (KPNC) Genetic Epidemiology Research on Adult Heath and Aging (GERA) cohort on 110,266 subjects. This sample is ideal because it is a single, large, multi-ethnic cohort with existing genome-wide genotype data linked to detailed electronic health records on individuals' refractive error and glaucoma diagnoses. The findings from this study will lay the foundation for mechanistic studies in animal models that recapitulate the features of myopia- induced glaucoma in humans.

Public Health Relevance

Refractive error is a risk factor for primary open angle glaucoma, and the prevalence of refractive error is rising across the world, indicating that it may play a growing role in the development of primary open angle glaucoma. The relationship between these two vision disorders, however, is poorly understood at a clinical, pathological, and mechanistic level. The goal of this project is to identify and characterize genetic loci underlying this association, which, in turn, will provide a foundation of future animal model investigations of the mechanisms linking refractive error and primary open angle glaucoma.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY027004-01A1
Application #
9259747
Study Section
Diseases and Pathophysiology of the Visual System Study Section (DPVS)
Program Officer
Liberman, Ellen S
Project Start
2017-07-01
Project End
2021-05-31
Budget Start
2017-07-01
Budget End
2018-05-31
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
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Choquet, Hélène; Paylakhi, Seyyedhassan; Kneeland, Stephen C et al. (2018) A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Nat Commun 9:2278
Jorgenson, Eric; Choquet, Hélène; Yin, Jie et al. (2018) Common Mitochondrial Haplogroups and Cutaneous Squamous Cell Carcinoma Risk. Cancer Epidemiol Biomarkers Prev 27:838-841
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Choquet, Hélène; Thai, Khanh K; Yin, Jie et al. (2017) A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. Nat Commun 8:2108