The objectives of this proposal are: 1) to map and chemically characterize the alloantigenic determinants of HLA-ABC and -DR antigens by isolating and characterizing mutants in cultured lymphoid cell lines with defined alterations in those molecules; 2) to map the determinants involved in the HLA restriction phenomenon observed in T-cell cell killing of virally infected human cells; 3) to continue to characterize and quantify mechanisms of genetic variation and effects of mutagens in human somatic cells by using HLA variants of dipolid cells; and 4) to elucidate the genetic organization of the HLA region using cloned HLA genes and deletion variants.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM015883-23
Application #
3268858
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1978-02-01
Project End
1988-03-31
Budget Start
1987-02-01
Budget End
1988-03-31
Support Year
23
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195