The primary object of this research is the development and exploration of methodology in NMR, especially in solids, from both a theoretical and an experimental viewpoint. Previous work along this line has led to innovations in technique which have had some impact on the study of biological systems, and it is hoped to continue similar progress. It is also planned to continue the application of recently developed methods, by studies of a) multiple coherence transfer and molecular connectivity, b) electron spin echo modulation and the structure of metalloproteins, c) broadband spin decoupling, d) slow molecular motion and others. An important part of the work in the second and following years, if preliminary explorations under other sponsorship are successful, will be the study of extremely rare or dilute species making use of the enormous increases in sensitivity which are available in principle at ultra-low temperatures.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM016552-17
Application #
3268964
Study Section
Biophysics and Biophysical Chemistry B Study Section (BBCB)
Project Start
1978-01-01
Project End
1988-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
17
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
Lee, C W; Waugh, J S; Griffin, R G (1986) Solid-state NMR study of trehalose/1,2-dipalmitoyl-sn-phosphatidylcholine interactions. Biochemistry 25:3737-42