Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM021199-28
Application #
2173672
Study Section
Biochemistry Study Section (BIO)
Project Start
1974-08-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
28
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Biochemistry
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Chen, Chi-hong B; Dellamaggiore, Kenneth R; Ouellette, Christopher P et al. (2008) Aptamer-based endocytosis of a lysosomal enzyme. Proc Natl Acad Sci U S A 105:15908-13
Hwang, Jae-Taeg; Baltasar, Francis E; Cole, Daniel L et al. (2003) Transcription inhibition using modified pentanucleotides. Bioorg Med Chem 11:2321-8
Chen, Chi-Hong B; Chernis, George A; Hoang, Van Q et al. (2003) Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3. Proc Natl Acad Sci U S A 100:9226-31
Xiao, Gaoping; Cole, Daniel L; Gunsalus, Robert P et al. (2002) Site-specific DNA cleavage of synthetic NarL sites by an engineered Escherichia coli NarL protein-1,10-phenanthroline cleaving agent. Protein Sci 11:2427-36
Chen, C B; Milne, L; Landgraf, R et al. (2001) Artificial nucleases. Chembiochem 2:735-40
Milne, L; Xu, Y; Perrin, D M et al. (2000) An approach to gene-specific transcription inhibition using oligonucleotides complementary to the template strand of the open complex. Proc Natl Acad Sci U S A 97:3136-41
Chen, C H; Landgraf, R; Walts, A D et al. (1998) Scission of DNA at a preselected sequence using a single-strand-specific chemical nuclease. Chem Biol 5:283-92
Gallagher, J; Chen, C H; Pan, C Q et al. (1996) Optimizing the targeted chemical nuclease activity of 1,10-phenanthroline-copper by ligand modification. Bioconjug Chem 7:413-20
Pan, C Q; Johnson, R C; Sigman, D S (1996) Identification of new Fis binding sites by DNA scission with Fis-1,10-phenanthroline-copper(I) chimeras. Biochemistry 35:4326-33
Landgraf, R; Pan, C; Sutton, C et al. (1996) Engineering of DNA binding proteins into site-specific cutters: reactivity of Trp repressor-1,10-phenanthroline chimeras. Protein Eng 9:603-10

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