Abstract

The overall objective of this research grant is to continue the development of modern statistical ideas for use in medical applications. This development involves the creation of new statistical methods, study of new and existing techniques through mathematical research and computer simulation, and trial application of these procedures to ongoing medical research projects at the Stanfdord Medical Center. The research will focus primarily on four specific areas: (1) forced randomization designs for clinical trials, (2) censored data analysis of survival times, (3) classification analysis for outcome prediction, and (4) robust/nonparametric methods of data analysis. The research will be conducted by the members of the Division of Biostatistics in the Stanford University School of Medicine. Application of the results of this statistical research to problems in cardiovascular research, cancer therapy clinical trials, and other areas is envisaged.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM021215-12
Application #
3270331
Study Section
(SSS)
Project Start
1977-07-01
Project End
1989-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
12
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Whittemore, A S; Halpern, J (1994) A class of tests for linkage using affected pedigree members. Biometrics 50:118-27
Whittemore, A S; Halpern, J (1994) Probability of gene identity by descent: computation and applications. Biometrics 50:109-17
Altman, R D; Medsger Jr, T A; Bloch, D A et al. (1991) Predictors of survival in systemic sclerosis (scleroderma). Arthritis Rheum 34:403-13
Carmelli, D; Halpern, J; Swan, G E et al. (1991) 27-year mortality in the Western Collaborative Group Study: construction of risk groups by recursive partitioning. J Clin Epidemiol 44:1341-51
Bloch, D A; Moses, L E; Michel, B A (1990) Statistical approaches to classification. Methods for developing classification and other criteria rules. Arthritis Rheum 33:1137-44
Kraemer, H C; Bloch, D A (1990) A note on case-control sampling to estimate kappa coefficients. Biometrics 46:49-59
Segal, M R; Bloch, D A (1989) A comparison of estimated proportional hazards models and regression trees. Stat Med 8:539-50
Bloch, D A; Kraemer, H C (1989) 2 x 2 kappa coefficients: measures of agreement or association. Biometrics 45:269-87
Kraemer, H C; Bloch, D A (1988) Kappa coefficients in epidemiology: an appraisal of a reappraisal. J Clin Epidemiol 41:959-68
Halpern, J; Brown Jr, B W (1987) Cure rate models: power of the logrank and generalized Wilcoxon tests. Stat Med 6:483-9

Showing the most recent 10 out of 12 publications