Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM021643-13
Application #
3270615
Study Section
Biochemistry Study Section (BIO)
Project Start
1978-05-01
Project End
1987-09-29
Budget Start
1987-05-01
Budget End
1987-09-29
Support Year
13
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Yeh, Ellen; Cole, Lindsay J; Barr, Eric W et al. (2006) Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH. Biochemistry 45:7904-12
Liu, Fei; Garneau, Sylvie; Walsh, Christopher T (2004) Hybrid nonribosomal peptide-polyketide interfaces in epothilone biosynthesis: minimal requirements at N and C termini of EpoB for elongation. Chem Biol 11:1533-42
Lessard, I A; Walsh, C T (1999) Mutational analysis of active-site residues of the enterococcal D-ala-D-Ala dipeptidase VanX and comparison with Escherichia coli D-ala-D-Ala ligase and D-ala-D-Ala carboxypeptidase VanY. Chem Biol 6:177-87
Lessard, I A; Walsh, C T (1999) VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function? Proc Natl Acad Sci U S A 96:11028-32
Stoll, V S; Simpson, S J; Krauth-Siegel, R L et al. (1997) Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry 36:6437-47
Rennex, D; Cummings, R T; Pickett, M et al. (1993) Role of tyrosine residues in Hg(II) detoxification by mercuric reductase from Bacillus sp. strain RC607. Biochemistry 32:7475-8
Smith, K; Nadeau, K; Bradley, M et al. (1992) Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata. Protein Sci 1:874-83
Moore, M J; Miller, S M; Walsh, C T (1992) C-terminal cysteines of Tn501 mercuric ion reductase. Biochemistry 31:1677-85
Leichus, B N; Bradley, M; Nadeau, K et al. (1992) Kinetic isotope effect analysis of the reaction catalyzed by Trypanosoma congolense trypanothione reductase. Biochemistry 31:6414-20
Walsh, C; Bradley, M; Nadeau, K (1992) Molecular studies on trypanothione reductase: an antiparasitic target enzyme. Curr Top Cell Regul 33:409-17

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