Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM024035-16
Application #
2174196
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1977-07-01
Project End
1998-05-31
Budget Start
1995-06-01
Budget End
1998-05-31
Support Year
16
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Kansas
Department
Biochemistry
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

Li, Hong; Tremblay, Jacqueline M; Yarbrough, Lynwood R et al. (2002) Both isoforms of mammalian phosphatidylinositol transfer protein are capable of binding and transporting sphingomyelin. Biochim Biophys Acta 1580:67-76
Yoder, M D; Thomas, L M; Tremblay, J M et al. (2001) Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine. J Biol Chem 276:9246-52
Tremblay, J M; Li, H; Yarbrough, L R et al. (2001) Modifications of cysteine residues in the solution and membrane-associated conformations of phosphatidylinositol transfer protein have differential effects on lipid transfer activity. Biochemistry 40:9151-8
Tremblay, J M; Voziyan, P A; Helmkamp Jr, G M et al. (1998) The C-terminus of phosphatidylinositol transfer protein modulates membrane interactions and transfer activity but not phospholipid binding. Biochim Biophys Acta 1389:91-100
Voziyan, P A; Tremblay, J M; Yarbrough, L R et al. (1997) Importance of phospholipid in the folding and conformation of phosphatidylinositol transfer protein: comparison of apo and holo species. Biochemistry 36:10082-8
Voziyan, P A; Tremblay, J M; Yarbrough, L R et al. (1996) Truncations of the C-terminus have different effects on the conformation and activity of phosphatidylinositol transfer protein. Biochemistry 35:12526-31
Tremblay, J M; Helmkamp, G M; Yarbrough, L R (1996) Limited proteolysis of rat phosphatidylinositol transfer protein by trypsin cleaves the C terminus, enhances binding to lipid vesicles, and reduces phospholipid transfer activity. J Biol Chem 271:21075-80
Dickeson, S K; Helmkamp Jr, G M; Yarbrough, L R (1994) Sequence of a human cDNA encoding phosphatidylinositol transfer protein and occurrence of a related sequence in widely divergent eukaryotes. Gene 142:301-5
Borror, C A; Helmkamp Jr, G M (1991) Transport of phosphatidylinositol to rat hepatocyte plasma membrane catalyzed by phosphatidylinositol transfer protein. Biochim Biophys Acta 1068:52-60
Khan, Z U; Helmkamp Jr, G M (1990) Stimulation of cholinephosphotransferase activity by phosphatidylcholine transfer protein. Regulation of membrane phospholipid synthesis by a cytosolic protein. J Biol Chem 265:700-5

Showing the most recent 10 out of 18 publications