We propose basic photochemical studies relevant to the synthesis of 1 alpha,25-dihydroxyvitamin D3, phototherapy of psoriasis, phototherapy of neonatal jaundice, and skin photosensitization by medicines and pesticides. Our long range goal is a molecular level understanding of photochemical and photobiological phenomena which will have predictive value for the future. Our immediate objectives are (1) an efficient in vitro synthesis of 1 alpha,25-dihydroxyvitamin D3, (2) a better understanding of the molecular details of steroid photochemistry, (3) utilization of photochemical methods in synthesis, (4) utilization of reactive intermediates in synthesis, (5) synthesis of reactive molecules of theoretical interest, and (6) a better understanding of heterocyclic photochemistry. Our unique low temperature (1.3 degrees K-80 degrees K) photochemical techniques offer special advantages in these studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM024427-11
Application #
3272294
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1977-09-01
Project End
1987-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Arts and Sciences
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095