Electrochemical methods for the quantifiably controlled delivery of biologically active compounds to well-defined locations will be developed. In one method the active substance will be bound in a polymer to the surface of a solid electrode. It will be released electrochemically. In a second method, an electronically switchable membrane will be used to control the flow of ionic substances. Compounds to be delivered include neurotransmitters and a variety of ionic drugs. Electroactive polymers which covalently bind drugs and conducting polymers which ionically bind drugs will be developed. These electrodes and membranes will be tested as an alternative to iontophoresis and timed-release drug delivery devices with release rate control and on/off capability will be explored.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM024493-09
Application #
3272351
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1978-12-01
Project End
1988-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
9
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Arts and Sciences
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455