Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM026020-18
Application #
2174588
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1978-12-01
Project End
1999-11-30
Budget Start
1995-12-07
Budget End
1996-11-30
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Clarke, Steven G (2018) The ribosome: A hot spot for the identification of new types of protein methyltransferases. J Biol Chem 293:10438-10446
Kafková, Lucie; Debler, Erik W; Fisk, John C et al. (2017) The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex. J Biol Chem 292:2089-2100
Hadjikyriacou, Andrea; Clarke, Steven G (2017) Caenorhabditis elegans PRMT-7 and PRMT-9 Are Evolutionarily Conserved Protein Arginine Methyltransferases with Distinct Substrate Specificities. Biochemistry 56:2612-2626
Lowenson, Jonathan D; Shmanai, Vadim V; Shklyaruck, Denis et al. (2016) Deuteration protects asparagine residues against racemization. Amino Acids 48:2189-96
Al-Hadid, Qais; White, Jonelle; Clarke, Steven (2016) Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. Biochem Biophys Res Commun 470:552-557
Debler, Erik W; Jain, Kanishk; Warmack, Rebeccah A et al. (2016) A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase. Proc Natl Acad Sci U S A 113:2068-73
Jain, Kanishk; Warmack, Rebeccah A; Debler, Erik W et al. (2016) Protein Arginine Methyltransferase Product Specificity Is Mediated by Distinct Active-site Architectures. J Biol Chem 291:18299-308
Al-Hadid, Qais; Roy, Kevin; Chanfreau, Guillaume et al. (2016) Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity. RNA 22:489-98
Caslavka Zempel, Katelyn E; Vashisht, Ajay A; Barshop, William D et al. (2016) Determining the Mitochondrial Methyl Proteome in Saccharomyces cerevisiae using Heavy Methyl SILAC. J Proteome Res 15:4436-4451
Hadjikyriacou, Andrea; Yang, Yanzhong; Espejo, Alexsandra et al. (2015) Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. J Biol Chem 290:16723-43

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