Mesner, Larry D; Dijkwel, Pieter A; Hamlin, Joyce L (2015) Purification of restriction fragments containing replication intermediates from complex genomes for 2-D gel analysis. Methods Mol Biol 1300:261-77
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Mesner, Larry D; Valsakumar, Veena; Cieslik, Marcin et al. (2013) Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early- and late-firing origins. Genome Res 23:1774-88
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Wong, Philip G; Winter, Sherry L; Zaika, Elena et al. (2011) Cdc45 limits replicon usage from a low density of preRCs in mammalian cells. PLoS One 6:e17533
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Mesner, Larry D; Valsakumar, Veena; Karnani, Neerja et al. (2011) Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription. Genome Res 21:377-89
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Hamlin, Joyce L; Mesner, Larry D; Dijkwel, Pieter A (2010) A winding road to origin discovery. Chromosome Res 18:45-61
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Mesner, Larry D; Hamlin, Joyce L (2009) Isolation of restriction fragments containing origins of replication from complex genomes. Methods Mol Biol 521:315-28
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Mesner, Larry D; Dijkwel, Pieter A; Hamlin, Joyce L (2009) Purification of restriction fragments containing replication intermediates from complex genomes for 2-D gel analysis. Methods Mol Biol 521:121-37
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Hamlin, J L; Mesner, L D; Lar, O et al. (2008) A revisionist replicon model for higher eukaryotic genomes. J Cell Biochem 105:321-9
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Czajkowsky, Daniel M; Liu, Jie; Hamlin, Joyce L et al. (2008) DNA combing reveals intrinsic temporal disorder in the replication of yeast chromosome VI. J Mol Biol 375:12-9
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Mesner, Larry D; Hamlin, Joyce L (2005) Specific signals at the 3' end of the DHFR gene define one boundary of the downstream origin of replication. Genes Dev 19:1053-66
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