It is planned to evaluate the specific stereochemical requirements of receptor sites for antitumor and antibacterial compounds. It is proposed to prepare a variety of polyterpenoid compounds which possess antitumor, antibacterial, antihypertensive and cytotoxic compounds. These compounds will be modified by substituents and by stereochemistry to have their biological activities determined. The proposed polyterpenoid research has as its basis naturally occurring compounds related to crassin acetate, phorbol, spatol, and pleuromutilin. New synthetic and degradative reactions of natural materials will be developed using high pressure techniques.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM027320-28
Application #
3274749
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1979-12-01
Project End
1990-07-31
Budget Start
1987-08-01
Budget End
1988-07-31
Support Year
28
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704