We wish to obtain a clearer understanding of the genetic basis of immunological functions controlled by the mouse MHC or H-2 complex through the analysis of its mutants. We will search for new mutations within the H-2 complex and in particular in the K, D, and I regions by skin grafting and serological techniques, and also for recessive lethal alleles (non-t-series) in Chromosome 17. We wish to study the genetic fine structure of the K and D regions in which numerous mutants are known and to define individual gene loci in those regions by modern genetic methods. Our studies will include functional analysis of the gene products of the mutants found.
|Egorov, O S; Liu, Y; Sargent, E E et al. (1992) Screening mouse mutations for resistance to cancer metastasis. Immunogenetics 36:219-23|
|Egorov, O S; Liu, Y; Egorov, I K (1992) Possible role of Abb gene in mouse resistance to EL4 metastases. Immunogenetics 36:213-8|
|Egorov, I K; Egorov, O S (1988) Detection of new MHC mutations in mice by skin grafting, tumor transplantation and monoclonal antibodies: a comparison. Genetics 118:287-98|
|Robinson, C J; Balazs, T; Egorov, I K (1986) Mercuric chloride-, gold sodium thiomalate-, and D-penicillamine-induced antinuclear antibodies in mice. Toxicol Appl Pharmacol 86:159-69|
|Nadeau, J H; Phillips, S J; Egorov, I K (1985) Recombination between the t6 complex and linked loci in the house mouse. Genet Res 45:251-64|