The proposed research deals with the incorporation of highly functionalized heterocycles into a cyclophane network which, via one or more mild and efficient chemical events, is unmasked to afford the skeleton characteristic of the cyclo-peptide alkaloids. Each is discussed, therefore, as potential intermediates which are to function as latent diamide/dipeptide equivalents in these schemes. Preliminary work has demonstrated the viability of such an approach in two acyclic systems. The natural products show considerable promise as ionophoric agents, in addition to other biological activities.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM028128-05
Application #
3275381
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1980-08-01
Project End
1988-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of California Santa Barbara
Department
Type
Schools of Arts and Sciences
DUNS #
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106