Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM028928-07
Application #
3276299
Study Section
Biophysics and Biophysical Chemistry A Study Section (BBCA)
Project Start
1981-01-01
Project End
1990-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
7
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Virginia
Department
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Veldhuis, J D; Johnson, M L (2000) Analysis of nonequilibrium facets of pulsatile sex-steroid secretion in presence of plasma-binding proteins. Methods Enzymol 321:239-63
Veldhuis, J D; Faunt, L M; Johnson, M L (1994) Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins. Methods Enzymol 240:349-77
Johnson, M L (1994) Dimer-tetramer equilibrium in Adair fitting. Methods Enzymol 232:597-606
Veldhuis, J D; Johnson, M L (1994) Testing pulse detection algorithms with simulations of episodically pulsatile substrate, metabolite, or hormone release. Methods Enzymol 240:377-415
Veldhuis, J D; Johnson, M L (1994) Analytical methods for evaluating episodic secretory activity within neuroendocrine axes. Neurosci Biobehav Rev 18:605-12
Veldhuis, J D; Johnson, M L; Faunt, L M et al. (1993) Influence of the high-affinity growth hormone (GH)-binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH. Modeling analysis and clinical applications. J Clin Invest 91:629-41
Lampl, M; Johnson, M L (1993) A case study of daily growth during adolescence: a single spurt or changes in the dynamics of saltatory growth? Ann Hum Biol 20:595-603
Straume, M; Johnson, M L (1992) Analysis of residuals: criteria for determining goodness-of-fit. Methods Enzymol 210:87-105
Straume, M; Johnson, M L (1992) Monte Carlo method for determining complete confidence probability distributions of estimated model parameters. Methods Enzymol 210:117-29
Veldhuis, J D; Johnson, M L; Seneta, E et al. (1992) Temporal coupling among luteinizing hormone, follicle stimulating hormone, beta-endorphin and cortisol pulse episodes in vivo. Acta Endocrinol (Copenh) 126:193-200

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