Abstract

This project involves the development of a number of new reactions and concepts for Organic Synthesis. The potential for our bisannulation strategy in the convergent synthesis of polycyclic molecules will be examined. New functionalized pentadienyl anions for intramolecular Diels-Alder reactions will be investigated. The synthesis of 25-hydroxy vitamin D will be carried out. Several routes to a taxane molecule suitably functionalized for further elaboration will be studied. The intramolecular Diels-Alder reaction of benzofurans will be investigated as a potential route to morphine.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM029259-04
Application #
3276824
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1980-09-01
Project End
1986-09-14
Budget Start
1985-07-01
Budget End
1986-09-14
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
Schools of Arts and Sciences
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Wilson, S R; Cui, W L (1990) Applications of simulated annealing to peptides. Biopolymers 29:225-35
Spector, A; Wilson, S R; Zucker, P A et al. (1989) The synthesis of glutathione peroxidase analogs. Lens Eye Toxic Res 6:773-80