Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM029840-25
Application #
2175655
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1982-01-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
25
Fiscal Year
1995
Total Cost
Indirect Cost
Name
West Virginia University
Department
Pharmacology
Type
Schools of Dentistry
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Roberts, M I; Stadel, J M; Torphy, T J et al. (1997) Mechanisms of adaptive supersensitivity: correlation of guinea pig atrial supersensitivity with modifications in adenylyl cyclase activity. Biochem Pharmacol 53:347-56
Caveney, S W; Taylor, D A; Fleming, W W (1997) Examination by radioligand binding of the alpha1 adrenoceptors in the mesenteric arterial vasculature during the development of salt-sensitive hypertension. Naunyn Schmiedebergs Arch Pharmacol 356:374-82
Kong, J Q; Taylor, D A; Fleming, W W (1995) Sustained hypertension in Dahl rats. Negative correlation of agonist response to blood pressure. Hypertension 25:139-45
Hershman, K M; Taylor, D A; Fleming, W W (1995) Adaptive supersensitivity and the Na+/K+ pump in the guinea pig vas deferens: time course of the decline in the alpha 2 subunit. Mol Pharmacol 47:726-9
Gould, E M; Curto, K A; Craig, C R et al. (1995) The role of GABAA receptors in the subsensitivity of Purkinje neurons to GABA in genetic epilepsy prone rats. Brain Res 698:62-8
Kong, J Q; Taylor, D A; Fleming, W W (1994) Functional distribution and role of alpha-1 adrenoceptor subtypes in the mesenteric vasculature of the rat. J Pharmacol Exp Ther 268:1153-9
Bexis, S; Lungershausen, Y K; Mano, M T et al. (1994) Dietary fish oil administration retards blood pressure development and influences vascular properties in the spontaneously hypertensive rat (SHR) but not in the stroke prone-spontaneously hypertensive rat (SHR-SP). Blood Press 3:120-6
Hershman, K M; Fleming, W W; Taylor, D A (1993) A quantitative method for assessing protein abundance using enhanced chemiluminescence. Biotechniques 15:790, 792, 794 passim
Hershman, K M; Taylor, D A; Fleming, W W (1993) Adaptive supersensitivity in the guinea pig vas deferens is associated with a reduction in the abundance of the alpha 2 subunit isoform of Na+/K(+)-ATPase. Mol Pharmacol 43:833-7
Roberts, M I; Biser, P S; Stadel, J M et al. (1992) Adenylyl cyclase and guanine nucleotide-binding proteins in supersensitive guinea pig ventricles. Mol Pharmacol 42:784-91

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